Vital involvement of a natural killer cell activation receptor in resistance to viral infection
Vital involvement of a natural killer cell activation receptor in resistance to viral infection
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DOI：
10.1126/science.1060042
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发表时间：
2001-05-04
期刊：
影响因子：
56.9
通讯作者：
Yokoyama, WM
中科院分区：
文献类型：
--
作者：
Brown, MG;Dokun, AO;Yokoyama, WM
自然杀伤（NK）细胞是淋巴细胞，其可通过其参与先天免疫和其缺乏重排抗原受体而与T和B细胞区分开。虽然NK细胞及其受体最初的特点是在体外杀死肿瘤，我们已经确定，NK细胞活化受体，Ly-49 H，是关键参与抵抗鼠巨细胞病毒在体内。Ly-49 H需要一个含有免疫受体酪氨酸激活基序（ITAM）的跨膜分子进行表达和信号转导。因此，NK细胞使用功能上类似于ITAM偶联的T和B细胞抗原受体的受体来提供重要的先天宿主防御。
Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.