Computer modelling of the cerebrospinal fluid flow dynamics of aqueduct stenosis
Computer modelling of the cerebrospinal fluid flow dynamics of aqueduct stenosis
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DOI：
10.1007/bf02513267
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发表时间：
1999-01-01
影响因子：
3.2
通讯作者：
Johnston, IH
中科院分区：
文献类型：
--
作者：
Jacobson, EE;Fletcher, DF;Johnston, IH
As the craniospinal space is a pressure loaded system it is difficult to conceptualise and understand the flow dynamics through the ventricular system. Aqueduct stenosis compromises flow, increasing the pressure required to move cerebrospinal fluid (CSF) through the ventricles. Under normal circumstances, less than one pascal (1 Pa) of pressure is required to move a physiological flow of CSF through the aqueduct. This is too small to measure using clinical pressure transducers. A computational fluid dynamics (CFD) program, CFX, has been used to model two forms of aqueduct stenosis: simple narrowing and forking of the aqueduct. This study shows that with mild stenoses, the increase in pressure required to drive flow becomes significant (86-125Pa), which may result in an increased transmantle pressure difference but not necessarily an increased intraventricular pressure. Severe stenoses will result in both. Wall shear stresses increase concomitantly and may contribute to local damage of the aqueduct wall and further gliosis with narrowing.
