Aberrant Hippocampal Connectivity in Unmedicated Patients With Schizophrenia and Effects of Antipsychotic Medication: A Longitudinal Resting State Functional MRI Study
Aberrant Hippocampal Connectivity in Unmedicated Patients With Schizophrenia and Effects of Antipsychotic Medication: A Longitudinal Resting State Functional MRI Study
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DOI：
10.1093/schbul/sbv228
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发表时间：
2016-07-01
影响因子：
6.6
通讯作者：
Lahti, Adrienne Carol
中科院分区：
文献类型：
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作者：
Kraguljac, Nina Vanessa;White, David Matthew;Lahti, Adrienne Carol
为了更好地表征精神分裂症海马的病理生理学，我们进行了一项纵向研究，评估海马功能连接在静息状态下，使用种子规定在其前部和后部区域。我们招募了34名未经药物治疗的精神分裂症或情感性精神障碍（SZ）患者和34名匹配的健康对照。22例患者停药后进行扫描，并给予利培酮治疗6周后再次扫描。组的连通性差异，以及随着时间的推移，连接的变化，进行了评估组的参与者水平的功能连接地图。我们发现未用药SZ的前海马和后海马种子显著连接障碍。SZ患者海马与前扣带皮层、尾状核、听觉皮层和距状沟之间的基线连接可预测抗精神病药物的后续反应。这些相同的区域在6周治疗试验中表现出与症状改善相关的变化。我们的研究结果涉及几个与抗精神病药物临床改善相关的神经网络。
To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating hippocampal functional connectivity during resting state, using seeds prescribed in its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (SZ) and 34 matched healthy controls. SZ were scanned while off medication, then were treated with risperidone for 6 weeks and rescanned (n = 22). Group differences in connectivity, as well as changes in connectivity over time, were assessed on the group's participant level functional connectivity maps. We found significant dysconnectivity with anterior and posterior hippocampal seeds in unmedicated SZ. Baseline connectivity between the hippocampus and anterior cingulate cortex, caudate nucleus, auditory cortex and calcarine sulcus in SZ predicted subsequent response to antipsychotic medications. These same regions demonstrated changes over the 6-week treatment trial that were correlated with symptomatic improvement. Our findings implicate several neural networks relevant to clinical improvement with antipsychotic medications.