Studies on Erysipelothrix rhusiopathiæ
Studies on Erysipelothrix rhusiopathiæ
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猪红斑丹毒丝菌病的研究
DOI：
10.1002/path.1700500214
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发表时间：
1940
期刊：
影响因子：
--
通讯作者：
P. Watts
中科院分区：
文献类型：
--
作者：
P. Watts
为了确定猪丹毒血清治疗的偶然失败是否可能是由于猪丹毒菌株之间的抗原差异。rhusiopathiae， W.对来自世界各地的43个菌株进行了研究。培养特征表明菌株在生物学上是相似的。凝集试验表明，它们大致可以分为两类，大多数属于一类，只有五类属于另一类；进一步的测试，凝集，凝集素吸收和生物学，证实了这一点。各组与毒力之间没有相关性。每一组都有一个热稳定的特异性抗原，另外每一组都可能含有两个热不稳定抗原，这两个抗原在两组中以不同的比例存在。这些后一种抗原似乎在抵抗感染方面是重要的，因为含有这些抗原的低效抗体的血清可以保护小鼠免受同一组中许多致命剂量的生物体的感染。在猪身上进行实地试验以证明接种疫苗后的保护作用，结果为阴性，而皮内试验以测试主动免疫，结果表明，配方疫苗未能保护猪免受最小感染剂量的影响。r·劳森。
To ascertain whether the occasional failures in swine erysipelas serum therapy might be due to antigenic differences between strains ofE. rhusiopathiae, W. carried out a study of 43 strains obtained from various parts of the world. Cultural characteristics showed the strains to be biologically similar. Agglutination tests showed that they could be divided roughly into two groups, the large majority falling into one group and only five into the other; further tests, agglutination, agglutinin absorption and biological, confirmed this. No correlation between groups and virulence could be ascertained. Each group possessed a heat-stable specific antigen, and in addition each probably contained two heat-labile antigens, which were present in different proportions in the two groups. These latter antigens would appear to be the important ones with regard to resistance to infection, since sera of low potency containing antibodies to them protected mice against many lethal doses of an organism of the same group. Field trials with swine to demonstrate protection following vaccination gave negative results, and intradermal tests to test active immunization showed that formolized vaccine failed to protect plgs against a minimal infective dose.-J. R. LAWSON.