Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese
Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese
复制标题
DOI：
10.1111/j.1365-2265.2011.04016.x
复制
发表时间：
2011-08-01
影响因子：
3.2
通讯作者：
Li, Youming
中科院分区：
文献类型：
--
作者：
Xu, Chengfu;Xu, Lei;Li, Youming
目的甲状腺功能异常常见于老年人群，且甲状腺功能异常与某些肝脏异常有关。目的探讨甲状腺功能正常的老年人非酒精性脂肪性肝病（NAFLD）与甲状腺功能的关系，方法采用横断面研究方法，对宁波市镇海莲花医院878例甲状腺功能正常的老年人进行健康体检。NAFLD患者血清游离甲状腺素（FT 4）水平显著低于对照组（11.12 +/- 1.43 vs 11.58 +/- 1.47 pmol/l; P < 0.001）。NAFLD的患病率随着血清FT 4水平的升高而沿着下降（P < 0.001）。经年龄、性别、吸烟状况校正后的相关分析显示，血清FT 4水平与体重指数、腰围、甘油三酯、血尿酸水平呈负相关（均P <0. 05）。逐步Logistic回归分析显示，血清FT 4水平与老年人NAFLD的发病风险显著相关[OR：0.847，95%可信区间（CI）：0.743 ~ 0.966; P = 0.013]。
Objective Thyroid dysfunction commonly occurs in the elderly population and overt thyroid dysfunction is associated with some liver abnormalities. This study aimed to investigate the association of thyroid function with nonalcoholic fatty liver disease (NAFLD) in euthyroid elderly Chinese.Methods A cross-sectional study was performed among 878 euthyroid elderly Chinese who took their annual healthy examination at Zhenhai Lianhua Hospital, Ningbo, China.Results A total of 227 (25.85%) subjects fulfilled the diagnostic criteria of NAFLD. Patients with NAFLD had significantly lower levels of serum-free thyroxine (FT4) than controls (11.12 +/- 1.43 vs 11.58 +/- 1.47 pmol/l; P < 0.001). The prevalence rate of NAFLD decreased along with progressively higher serum FT4 levels (P for trend < 0.001). Age, gender and smoking status-adjusted correlation analysis showed that serum FT4 level was negatively correlated with body mass index, waist circumference, triglyceride and serum uric acid levels (All with P < 0.05). Stepwise logistic regression analysis showed that serum FT4 level was significantly associated with the risk for NAFLD [odds ratio (OR): 0.847, 95% confidence interval (CI): 0.743 - 0.966; P = 0.013].Conclusion Our findings suggest that thyroid function, even within the reference range, is associated with NAFLD in elderly Chinese.