Ultrastructure and three-dimensional imaging of epimyoepithelial islands in benign lymphoepithelial lesions
Ultrastructure and three-dimensional imaging of epimyoepithelial islands in benign lymphoepithelial lesions
复制标题
良性淋巴上皮病变中肌上皮岛的超微结构和三维成像
DOI：
10.1007/bf00168030
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发表时间：
2004
影响因子：
2.6
通讯作者：
T. Ishii
中科院分区：
文献类型：
--
作者：
Toshio Yoshihara;M. Morita;T. Ishii
与干燥综合征相关的唾液腺良性淋巴上皮病变的特征在于淋巴细胞的广泛浸润、腺泡萎缩和所谓的上皮岛的存在。这份报告描述了超微结构和三维重建的研究在东京女子医科大学进行的上皮岛。超微结构观察表明，这些岛主要由上皮细胞组成，含有中间丝和/或张力丝束，散在的淋巴细胞和浆细胞。在肌上皮岛的周边部分有时发现含有肌丝的肌上皮样细胞。此外，有丝分裂的数字很少发现在这些岛屿。三维重建显示，肌上皮岛不是孤立的细胞团，而是连续的肥大导管样结构。这些结果表明，上皮岛是来自增生的导管上皮细胞，特别是那些大的外周导管。
Benign lymphoepithelial lesions of the salivary glands associated with Sjbgren's syndrome are characterized by extensive infiltration of lymphoid cells, atrophy of acini and the presence of so-called epimyoepithelial islands. This report describes ultrastructural and three-dimensional reconstructive studies of epimyoepithelial islands performed at Tokyo Women's Medical College. Ultrastructural examination showed that these islands are composed mainly of epithelial cells containing intermediate filaments and/or tonofilament bundles, scattered lymphocytes and plasma cells. Myoepithelium-like cells containing myofilaments were sometimes found in the peripheral portion of the myoepithelial islands. Also, mitotic figures were rarely found in these islands. Three-dimensional reconstructive study revealed that the epimyoepithelial islands are not isolated cell clusters but are continuous hypertrophic duct-like structures. These results suggest that the epimyoepithelial islands are derived from proliferating duct epithelial cells, especially those of large peripheral ducts.