Reduction of orbital frontal cortex volume in geriatric depression
Reduction of orbital frontal cortex volume in geriatric depression
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DOI：
10.1016/s0006-3223(00)01042-8
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发表时间：
2000-11-15
影响因子：
10.6
通讯作者：
Krishnan, KRR
中科院分区：
文献类型：
--
作者：
Lai, TJ;Payne, ME;Krishnan, KRR
背景：尸检研究已经证实抑郁症患者的内侧眶额叶皮质异常。在这项研究中，我们评估是否可以确定在老年抑郁症患者使用磁共振imaging.Methods：20名老年患者符合DSM-IV标准的抑郁症和20个匹配的对照组进行了研究。使用磁共振成像测量两个半球的眶额皮质。结果：抑郁症患者的总眶额皮质、右眶额皮质和左眶额皮质体积减少。我们发现大脑两侧的眶额皮质体积都减少了，这表明大脑的这一区域可能在抑郁和mises问题的发展中起着关键作用。这些变化的病因(C)2000年生物精神病学学会。
Background: Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging.Methods: Twenty elderly patients meeting DSM-IV criteria for major depression and 20 matched control subjects were studied. The orbital frontal cortex was measured in both hemispheres using magnetic resonance imaging.Results: Depressive patients had reduced volume in the total orbital frontal cortex, right orbital frontal cortex, and left orbital frontal cortexConclusions: Our finding of a reduction in orbital frontal cortex volume in both sides of the brain suggests that this region of the brain may have a critical role in the development of depression and mises questions about the etiology of the changes. (C) 2000 Society of Biological Psychiatry.