Recent advances and developments in neural repair and regeneration for hand surgery.
Recent advances and developments in neural repair and regeneration for hand surgery.
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DOI：
10.2174/1874325001206010103
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Khan, Wasim
中科院分区：
文献类型：
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作者：
Chimutengwende-Gordon, Mukai;Khan, Wasim
神经的端到端缝合和自体神经移植是修复和重建周围神经的黄金标准。然而，组织胶无缝合神经修复、端侧神经修复和同种异体移植等技术作为替代方案存在。生物和合成神经导管在重建手部神经缺损的早期临床研究中取得了一定的成功。利用这些神经导管作为支架运送雪旺细胞、干细胞、神经营养因子和神经营养因子或细胞外基质蛋白，有可能提高神经再生的有效性。对这些技术已经进行了广泛的体外和体内研究。这些技术的临床适用性和有效性需要充分研究。
End-to-end suture of nerves and autologous nerve grafts are the 'gold standard' for repair and reconstruction of peripheral nerves. However, techniques such as sutureless nerve repair with tissue glues, end-to-side nerve repair and allografts exist as alternatives. Biological and synthetic nerve conduits have had some success in early clinical studies on reconstruction of nerve defects in the hand. The effectiveness of nerve regeneration could potentially be increased by using these nerve conduits as scaffolds for delivery of Schwann cells, stem cells, neurotrophic and neurotropic factors or extracellular matrix proteins. There has been extensive in vitro and in vivo research conducted on these techniques. The clinical applicability and efficacy of these techniques needs to be investigated fully.