BLOOD-LEVELS OF O,P'-DDD FOLLOWING ADMINISTRATION IN VARIOUS VEHICLES AFTER A SINGLE DOSE AND DURING LONG-TERM TREATMENT
BLOOD-LEVELS OF O,P'-DDD FOLLOWING ADMINISTRATION IN VARIOUS VEHICLES AFTER A SINGLE DOSE AND DURING LONG-TERM TREATMENT
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DOI：
10.1007/bf00258213
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发表时间：
1981-01-01
影响因子：
3
通讯作者：
SMEENK, D
中科院分区：
文献类型：
--
作者：
MOOLENAAR, AJ;VANSLOOTEN, H;SMEENK, D
单次口服给药后测定血浆o，p′-DDD水平。在治疗开始时，分别有9、12、14、10和6例患者接受了市售片剂和颗粒剂以及牛奶、巧克力和油乳剂中的o，p′-DDD。在巧克力、乳剂和牛奶中给药后，在前5小时和10小时内记录的平均血浆水平显著高于片剂给药后。22例肾上腺皮质癌患者接受200 g o，p′-DDD的维持治疗期间，也测定了血浆中o，p′-DDD浓度。在长期治疗结束后的血浆消失率为18 ~ 159天。口服片剂后粪便中o，p′-DDD的回收率比口服油乳剂和牛奶后约高5倍。就血浆浓度的快速升高和患者依从性而言，使用奶粉混合物获得的结果最好。
Plasma levels of o,p′-DDD were measured after ingestion of a single oral dose. At the onset of therapy o,p′-DDD was administered as commercially available tablets and granules and in milk, chocolate, and an oil emulsion to 9, 12, 14, 10, and 6 patients, respectively. Following administration in chocolate, emulsion, and milk significantly higher mean plasma levels were recorded in the first 5-and 10-h periods than after tablets. Granules gave significantly lower plasma levels than all other forms.Plasma levels were also measured during maintenance therapy, when a total of 200 g o,p′-DDD was administered to 22 patients with adrenocortical carcinoma. The plasma disappearance rate after termination of long-term therapy was found to be between 18 and 159 days.The recovery of o,p′-DDD from faeces was about five times higher after ingestion of tablets than after administration in oil emulsion and milk.As far as the rapid increase in plasma levels and patient compliance are concerned, the best results were obtained with the milk powder mixture.