Highly enantio- and diastereoselective construction of 1,2-disubstituted cyclopentane compounds by dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate]-catalyzed C-H insertion reactions of α-diazo esters
Highly enantio- and diastereoselective construction of 1,2-disubstituted cyclopentane compounds by dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate]-catalyzed C-H insertion reactions of α-diazo esters
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DOI：
10.1002/adsc.200505201
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发表时间：
2005-10-01
影响因子：
5.4
通讯作者：
Hashimoto, S
中科院分区：
文献类型：
--
作者：
Minami, K;Saito, H;Hashimoto, S
使用四[N-邻苯二甲酰-(S)-叔亮氨酸]二铑(II)作为催化剂，实现了α-重氮酯的高度对映和非对映选择性分子内C-H插入反应，仅提供高达95% ee的顺式-2-芳基环戊烷-1-羧酸酯，且没有形成烯烃的证据。
A highly enantio- and diastereoselective intramolecular C-H insertion reaction of alpha-diazo esters has been achieved with the use of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] as a catalyst, providing exclusively cis-2-arylcyclopentane-1 -carboxylates in up to 95% ee with no evidence of alkene formation.