Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus
Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus
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DOI：
10.1038/71145
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发表时间：
2000-01-01
影响因子：
25
通讯作者：
Nader, K
中科院分区：
文献类型：
--
作者：
Amorapanth, P;LeDoux, JE;Nader, K
引起恐惧的刺激会引起先天反应，并能加强新反应的获得。我们测试了调节这些条件刺激（CS）特性的机制是否在杏仁核内同构或可分离。大鼠接受恐惧调节任务（CS与脚震配对）的训练，然后接受逃避恐惧任务（EFF）的训练，其中CS加强了终止CS的运动反应。在EFF任务中，外侧核（LA）病变阻断了条件冻结反应的获得和CS对新反应的强化。中央核（CE）病变阻断条件冻结而不阻断EFF，而基底核(B)病变阻断条件冻结而不阻断EFF。因此，由CS激活的LA似乎通过CE触发条件反应，通过B激活触发条件厌恶，B的减少强化了新的行为。
Fear-arousing stimuli elicit innate reactions and can reinforce acquisition of new responses. We tested whether mechanisms mediating these conditioned stimulus (CS) properties were isomorphic or dissociable within the amygdala. Rats trained on a fear-conditioning task (CS paired with footshock) were then trained on an escape-from-fear task (EFF) in which the CS reinforced a locomotor response terminating the CS. Lateral nucleus (LA) lesions blocked acquisition of both conditioned freezing responses and the CS's reinforcement of a new response in the EFF task. Central nucleus (CE) lesions blocked conditioned freezing but not the EFF, whereas basal nucleus (B) lesions blocked the EFF but not conditioned freezing. Thus, activation of the LA by a CS seems to trigger conditioned reactions via CE and conditioned aversion via B activation, reduction of which reinforces new actions.