Flow properties of liquid calcium alginate polymer injected through medical microcatheters for endovascular embolization
Flow properties of liquid calcium alginate polymer injected through medical microcatheters for endovascular embolization
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DOI：
10.1002/jbm.10202
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发表时间：
2002-09-15
期刊：
影响因子：
--
通讯作者：
Kipke, DR
中科院分区：
文献类型：
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作者：
Becker, TA;Kipke, DR
研究了海藻酸钙液体注射液在血管内栓塞中的应用。用流变仪和控制注射系统评估了海藻酸盐的剪切性能。利用实验结果对海藻酸盐在不同医用微导管输送系统中的流动特性进行了建模和预测，结果表明海藻酸盐随着剪切量的增加而发生剪切变薄效应。在低注射压力（100 kPa）下，2.0 wt %海藻酸盐和牛顿流体（82 cP）从同一微导管注入的流量比较显示，两者的流速相似。然而，在高注入压力（2100 kPa）下，海藻酸盐的注入流速比牛顿流体高100%。通过微导管对注射进行进一步分析，建立了一个流动模型，用于预测液体海藻酸盐在中高剪切速率下的粘度变化、流速和注射压力。预测的注射压力和流速与实验流动数据的平均方差小于15%。本研究表明海藻酸钙具有通过血管内注射成功输送到血管病变的必要流动特性。海藻酸盐的可能用途包括治疗动静脉畸形（AVMs）、动脉瘤、流向肿瘤的血液和血管出血。(C) 2002 Wiley期刊有限公司
The flow properties of liquid calcium alginate injections were investigated for application in endovascular embolization. Alginate shear properties were assessed with a rheometer and a controlled injection system. The experimental results were used to model the flow properties and predict alginate's flow characteristics within various medical microcatheter delivery systems, The results suggest that alginates undergo shear-thinning effects with increasing shear. A flow comparison of 2.0 wt % alginate and a Newtonian fluid (82 cP) injected from the same microcatheter had similar flow rates at low injection pressure (100 kPa). However, at high injection pressure (2100 kPa), the alginate was injectable at a flow rate 100% higher than was the Newtonian fluid. Further analysis of injections through microcatheters resulted in a flow model for predicting viscosity changes, flow rates, and injection pressures of liquid alginate at medium-to-high shear rates. The predicted injection pressures and flow rates had an average variance of less than 15% from that of the experimental flow data. This study indicates that calcium alginate has the requisite flow properties for successful delivery to vascular lesions via endovascular injection. Possible uses of alginates include treating arteriovenous malformations (AVMs), aneurysms, blood flow to tumors, and vascular hemorrhages. (C) 2002 Wiley Periodicals, Inc.