Control of topographic retinal axon branching by inhibitory membrane-bound molecules.
Control of topographic retinal axon branching by inhibitory membrane-bound molecules.
复制标题
通过抑制性膜结合分子控制地形视网膜轴突分支。
DOI：
10.1126/science.8047886
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
O'Leary,DD
中科院分区：
文献类型：
--
作者：
Roskies,AL;O'Leary,DD
非哺乳动物脊椎动物的视网膜专题图发育似乎是由引导或限制视网膜轴突在其目标中的正确位置的分子控制的。然而，大鼠上丘（SC）的视网膜专题图是通过侧支分支和树枝化的地形偏差而形成的。颞部视网膜轴突从胚胎大鼠的地形正确的喙侧 SC 或不正确的尾侧 SC 延伸穿过交替的膜，优先在吻侧膜上分支。分支偏好是由于尾侧 SC 中的抑制性磷脂酰肌醇连接分子所致。因此，位置编码膜结合分子可以通过调节轴突分支而不是通过指导轴突生长来在哺乳动物中建立视网膜专题图。
Retinotopic map development in nonmammalian vertebrates appears to be controlled by molecules that guide or restrict retinal axons to correct locations in their targets. However, the retinotopic map in the superior colliculus (SC) of the rat is developed instead by a topographic bias in collateral branching and arborization. Temporal retinal axons extending across alternating membranes from the topographically correct rostral SC or the incorrect caudal SC of embryonic rats preferentially branch on rostral membranes. Branching preference is due to an inhibitory phosphatidylinositol-linked molecule in the caudal SC. Thus, position-encoding membrane-bound molecules may establish retinotopic maps in mammals by regulating axon branching, not by directing axon growth.