Double-parabolic-reflectors acoustic waveguides for high-power medical ultrasound
Double-parabolic-reflectors acoustic waveguides for high-power medical ultrasound
复制标题
用于高功率医疗超声的双抛物面反射器声波导
DOI：
10.1038/s41598-019-54916-2
复制
发表时间：
2019
影响因子：
4.6
通讯作者：
T. Morita
中科院分区：
文献类型：
--
作者：
Kang Chen;T. Irie;T. Iijima;T. Morita
高强度聚焦超声治疗被广泛用于非侵入性治疗各种类型的原发性肿瘤和转移瘤。然而，超声穿透深度随着频率的增加而变浅，这限制了对深部组织的治疗精度。虽然声波导通常被插入到组织中用于局部治疗，但是强大的超声递送是困难的。在这里，我们发明了双抛物面反射器声波波导，其中高功率超声发射和大的机械振动提高了治疗效率。通过两个抛物面反射器放大约20倍的高能量密度超声波在1至2 MHz之间通过薄波导传播，并且波导尖端处从1 kHz至2.5 MHz的宽带大机械振动加速治疗。这项基础性工作是未来生物医学应用的里程碑，从治疗到诊断。由于在高频下的高功率能力，我们的波导还将在医学，生物，物理等方面开辟新的研究领域。
High intensity focused ultrasound therapeutics are widely used to noninvasively treat various types of primary tumors and metastasis. However, ultrasound penetration depth is shallowed with increasing frequency which limits the therapeutic accuracy for deep tissues. Although acoustic waveguides are commonly inserted into tissue for localized therapy, powerful ultrasound delivery is difficult. Here, we invent double-parabolic-reflectors acoustic waveguides, where high-power ultrasound emission and large mechanical vibration enhance the therapeutic efficiency. High-energy-density ultrasound with around 20 times amplification by two parabolic reflectors propagates through the thin waveguide between 1 to 2 MHz, and wideband large mechanical vibration at the waveguide tip from 1 kHz to 2.5 MHz accelerates the therapeutics. This fundamental work serves as a milestone for future biomedical applications, from therapeutics to diagnostics. Since the high-power ability at high frequencies, our waveguide will also open up new research fields in medical, bio, physics and so on.
小型圆柱形超声波源，用于通过体腔或间质植入物诱导高温。
DOI：
10.3109/02656739309022539
发表时间：
1993
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Hynynen,K;Davis,KL
通讯作者：
Davis,KL
影响因子：
2.4
作者：
Canney, Michael S.;Bailey, Michael R.;Sapozhnikov, Oleg A.
通讯作者：
Sapozhnikov, Oleg A.
影响因子：
48
作者：
Ozcelik A;Rufo J;Guo F;Gu Y;Li P;Lata J;Huang TJ
通讯作者：
Huang TJ