Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in Isolated Rapid Eye Movement Sleep Behavior Disorder.
Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in Isolated Rapid Eye Movement Sleep Behavior Disorder.
复制标题
孤立性快速眼动睡眠行为障碍中的胆碱能核 4 变性和认知障碍。
DOI：
10.1002/mds.29306
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Barrett,MatthewJ
中科院分区：
文献类型：
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作者：
Tan,Christopher;Nawaz,Huma;Lageman,SarahK;Cloud,LeslieJ;Amara,AmyW;Newman,BenjaminT;Druzgal,TJason;Berman,BrianD;Mukhopadhyay,Nitai;Barrett,MatthewJ
研究背景4号胆碱能核（Ch4）变性与帕金森病和路易体痴呆的认知障碍有关，但尚不清楚Ch4变性是否也存在于孤立的快速眼动睡眠行为障碍（iRBD）中目的是确定iRBD患者是否存在Ch4变性的证据，以及是否与认知障碍相关。35名iRBD患者和35名年龄和性别匹配的健康对照的神经心理学数据。结果iRBD组Ch4区GMD明显低于对照组（0. 417 vs. 0. 441，P = 0. 02）。Ch4 GMD也被发现是字母数字排序的显著预测因子（β系数= 58.31，P = 0.026，95%置信区间[7.47，109.15]），这是一种工作记忆的测量方法。© 2023 The Authors.Movement Disorder由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
BackgroundCholinergic nucleus 4 (Ch4) degeneration is associated with cognitive impairment in Parkinson's disease and dementia with Lewy bodies, but it is unknown if Ch4 degeneration is also present in isolated rapid eye movement sleep behavior disorder (iRBD).ObjectiveThe aim was to determine if there is evidence of Ch4 degeneration in patients with iRBD and if it is associated with cognitive impairment.MethodsWe analyzed the clinical and neuropsychological data of 35 iRBD patients and 35 age‐ and sex‐matched healthy controls. Regional gray matter density (GMD) was calculated for Ch4 using probabilistic maps applied to brain magnetic resonance imaging (MRI).ResultsCh4 GMD was significantly lower in the iRBD group compared to controls (0.417 vs. 0.441,P= 0.02). Ch4 GMD was also found to be a significant predictor of letter number sequencing (β‐coefficient = 58.31,P= 0.026, 95% confidence interval [7.47, 109.15]), a measure of working memory.ConclusionsiRBD is associated with Ch4 degeneration, and Ch4 degeneration in iRBD is associated with impairment in working memory. © 2023 The Authors.Movement Disorderspublished by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.