Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients.
Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients.
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DOI：
10.3390/ijms17040578
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发表时间：
2016-04-19
影响因子：
5.6
通讯作者：
Verbanac D
中科院分区：
文献类型：
--
作者：
Matijašić M;Meštrović T;Perić M;Čipčić Paljetak H;Panek M;Vranešić Bender D;Ljubas Kelečić D;Krznarić Ž;Verbanac D
健康的肠道代表了一个显着的界面，其中无菌宿主组织与肠道微生物群接触，处于稳态平衡状态。肠道内稳态的失衡与许多严重病理状况的发作相关，例如炎症性肠病（IBD），一种发病率增加并严重影响受影响个体的慢性胃肠道病症。尽管下一代测序和生物信息学的最新发展，目前的科学知识的特定触发器和诊断标志物，以改善IBD的干预方法仍然是稀缺的。在这篇综述中，我们提出并讨论了目前可用的和新兴的治疗方案，以调节IBD患者肠道微生物群的组成和代谢活性。微生物群水平的治疗方法，例如单独或与益生菌，益生元和合生元一起的饮食干预，抗生素的施用，进行粪便微生物群移植（FMT）和使用线虫，都代表了建立和维持健康以及改善基础IBD症状的有希望的机会。
The healthy intestine represents a remarkable interface where sterile host tissues come in contact with gut microbiota, in a balanced state of homeostasis. The imbalance of gut homeostasis is associated with the onset of many severe pathological conditions, such as inflammatory bowel disease (IBD), a chronic gastrointestinal disorder increasing in incidence and severely influencing affected individuals. Despite the recent development of next generation sequencing and bioinformatics, the current scientific knowledge of specific triggers and diagnostic markers to improve interventional approaches in IBD is still scarce. In this review we present and discuss currently available and emerging therapeutic options in modulating composition and metabolic activity of gut microbiota in patients affected by IBD. Therapeutic approaches at the microbiota level, such as dietary interventions alone or with probiotics, prebiotics and synbiotics, administration of antibiotics, performing fecal microbiota transplantation (FMT) and the use of nematodes, all represent a promising opportunities towards establishing and maintaining of well-being as well as improving underlying IBD symptoms.