Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis
Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis
复制标题
软骨基质启发的仿生超润滑纳米球用于治疗骨关节炎
DOI：
10.1016/j.biomaterials.2020.119931
复制
发表时间：
2020-06-01
期刊：
影响因子：
14
通讯作者：
Zhang, Hongyu
中科院分区：
文献类型：
--
作者：
Chen, Hao;Sun, Tao;Zhang, Hongyu
自然关节的超润滑性归因于关节软骨的水化润滑。在这里，受磷脂酰胆碱类脂(一种典型的软骨基质)存在两性离子电荷的结构的启发，我们通过光聚合制备了超润滑纳米球，即聚(2-甲基丙烯酰氧乙基磷酰胆碱)接枝介孔二氧化硅纳米球(MSNS-NH2@PMPC)。仿生纳米球可以通过在聚合物刷子的两性离子电荷(PMPC)周围形成坚韧的水化层来增强润滑性，并利用纳米载体(MSN)实现抗炎药物的局部输送。摩擦学和药物释放测试表明，纳米球的润滑性和缓释性得到了改善。此外，体外和体内实验表明，超润滑载药纳米球通过上调软骨合成代谢成分，下调分解代谢酶和疼痛相关基因，抑制骨关节炎的发展。纳米球具有增强润滑和持续药物输送的综合特征，可以成为治疗骨关节炎的一种有效的关节内纳米药物。
The superlubrication of natural joint has been attributed to hydration lubrication of articular cartilage. Here, inspired by the structure of phosphatidylcholine lipid (a typical cartilage matrix) with the presence of zwitterionic charges, we developed superlubricated nanospheres, namely poly (2-methacryloyloxyethyl phosphorylcholine)-grafted mesoporous silica nanospheres (MSNs-NH2@PMPC), via photopolymerization. The biomimetic nanospheres could enhance lubrication due to the formation of a tenacious hydration layer surrounding the zwitterionic charges of polymer brushes (PMPC), and achieve local delivery of an anti-inflammatory drug employing the nanocarriers (MSNs). The tribological and drug release tests showed improved lubrication and sustained drug release of the nanospheres. Additionally, the in vitro and in vivo tests revealed that the superlubricated drug-loaded nanospheres inhibited the development of osteoarthritis by up-regulating cartilage anabolic components and down-regulating catabolic proteases and pain-related gene. The nanospheres, with an integrated feature of both enhanced lubrication and sustained drug delivery, can be an efficient intra-articular nanomedicine for the treatment of osteoarthritis.