Clay eating attenuates lithium-based taste aversion learning in rats: A remedial effect of kaolin on nausea.
Clay eating attenuates lithium-based taste aversion learning in rats: A remedial effect of kaolin on nausea.
复制标题
吃粘土会减弱大鼠基于锂的味觉厌恶学习：高岭土对恶心的治疗作用。
DOI：
10.1016/j.physbeh.2018.02.020
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发表时间：
2018
影响因子：
2.9
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Nakajima;S.
食用高岭土被认为是大鼠恶心的标志，因为各种引起人类恶心的治疗方法都会使大鼠食用高岭土。本研究通过两个实验复制了由呕吐性氯化锂（LiCl）注射诱导的高岭土摄食。然而，注射LiCl并没有使大鼠进食木制物品。本研究还提供了一项新的发现，即高岭土的摄入减轻了LiCl注射引起的大鼠的味觉厌恶学习。这一发现与食用高岭土不仅是一种有用的指标，而且是一种有效的药物引起的大鼠恶心的治疗方法的论点是一致的。
Kaolin clay eating has been considered as a marker of nausea in rats, because a variety of treatments, which evoke nausea in humans, generate consumption of kaolin clay in rats. The present study with two experiments replicated kaolin clay ingestion induced by an injection of emetic lithium chloride (LiCl). The LiCl injection, however, did not generate eating of wooden objects in rats. The present study also provides a new finding that consumption of kaolin clay alleviates rats' taste aversion learning caused by an LiCl injection. This finding is congruent with the contention that consumption of kaolin clay is not only a useful index of, but also an effective remedy for, drug-induced nausea in rats.