Intended intramuscular gluteal injections: Are they truly intramuscular?
Intended intramuscular gluteal injections: Are they truly intramuscular?
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DOI：
10.4103/0022-3859.132334
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发表时间：
2014-04-01
影响因子：
1.6
通讯作者：
Chandana, R.
中科院分区：
文献类型：
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作者：
Dayananda, L.;Belaval, V. V.;Chandana, R.
背景：对于肥胖患者，由于臀部脂肪增加，肌肉注射可能会沉积在皮下。我们的目的是利用我们研究所进行的腹部 CT 测量臀部脂肪厚度来检验我们的假设。材料和方法：IRB 批准后，对过去 6 个月的腹部和骨盆 CT 扫描进行分析。以标准化方式测量臀部皮下脂肪的厚度。结果：在研究的 700 例 CT 扫描中，476 例为男性，224 例为女性。平均臀肌厚度为 2.34 厘米 +/- 1 厘米。男性的平均脂肪厚度为 1.98 厘米 +/- 0.98 厘米，而女性为 3.0 厘米 +/- 1.2 厘米。皮下肉芽肿17例，肌内平面注射性肉芽肿1例。结论：大量女性患者的臀部脂肪厚度增加超出了常规使用的针头所能达到的范围。因此，这些患者的药物将无意中注射到皮下平面，可能会改变药代动力学。
Context: In patients with obesity, intramuscular injections may be deposited subcutaneously due to an increase in gluteal fat. We aimed to use abdominal CT done in our institute for gluteal fat thickness to test our hypothesis. Materials and Methods: After IRB approval, CT scans of the abdomen and pelvis of the past 6 months were analyzed. The thickness of gluteal region subcutaneous fat was measured in a standardized manner. Results: Out of 700 CT scans, studied, 476 were males and 224 were females. The average gluteal fat thickness was 2.34 cm +/- 1 cm. The average fat thickness in males was 1.98 cm +/- 0.98 cm whereas in females was 3.0 cm +/- 1.2 cm. Subcutaneous granulomas were seen in 17 cases and one injection granuloma in the intramuscular plane. Conclusion: A significant number of female patients had increased gluteal fat thickness beyond the reach of routinely used needles. The medications in these patients will thus be unintentionally injected to subcutaneous plane, possibly altering the pharmacokinetics.