Polyneuritis cranialis associated with industrial trichloroethylene poisoning.
Polyneuritis cranialis associated with industrial trichloroethylene poisoning.
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与工业三氯乙烯中毒有关的颅多发性神经炎。
DOI：
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发表时间：
1967
影响因子：
11
通讯作者：
M. Hayward
中科院分区：
文献类型：
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作者：
P. Buxton;M. Hayward
三氯乙烯在第一次世界大战期间被广泛用作溶剂和脱脂剂，1915年报告了第一批接触这种物质的工人的脑神经损伤病例。随后又有报道称，毒剂是一种污染物(Defalque，1961；Browning，1965)。杰克逊(1934)发表了一份关于三氯乙烯的麻醉特性的报告，但美国医学会药学和化学委员会(1936)批评他使用这种物质是因为早期报告的脑神经麻痹，并禁止在美国将其用作麻醉剂。五年后，休厄尔和哈德菲尔德(1941)将其引入英国麻醉实践，并发生了许多脑神经损伤的案例。很快就很明显，在这些案例中，闭路使用苏打石灰是致病因素，因为它导致了药物的分解(Firth和Stuckey，1945)。这种情况的避免有效地防止了任何进一步的灾难。脑神经损伤的病理以前没有被描述过；唯一可用的尸检是Humphrey和McClelland(1944)系列中的两个。
Trichloroethylene came into wide use as a solvent and degreasing agent during the First World War, and in 1915 the first cases of cranial nerve damage in workers exposed to this substance were reported. Further reports followed and it was suggested that the toxic agent was a contaminant (Defalque, 1961; Browning, 1965). Jackson (1934) published an account ofthe anaesthetic properties of trichloroethylene, but the Council on Pharmacy and Chemistry of the American Medical Association (1936) criticized his use of this substance because of the earlier reported cranial nerve palsies and inhibited its use as an anaesthetic agent in the United States. Five years later Hewer and Hadfield (1941) introduced it into British anaesthetic practice and a number of cases of cranial nerve damage occurred. It soon became evident that in these cases the use of soda lime in closed circuit was the causative factor, as it led to decomposition of the drug (Firth and Stuckey, 1945). Avoidance of such conditions effectively prevented any further mishaps. The pathology of the cranial nerve lesions has not been previously described; the only necropsies available were two in the series of Humphrey and McClelland (1944).