Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages
Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages
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DOI：
10.1007/s11418-010-0395-8
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发表时间：
2010-04-01
影响因子：
3.3
通讯作者：
Matsuda, Hideaki
中科院分区：
文献类型：
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作者：
Inaba, Kazunori;Murata, Kazuya;Matsuda, Hideaki
连续口服给药（50 mg/kg）的50%乙醇提取物（HP-ext）的魔鬼的爪，二次根Harpagophytum平卧，显示出显着的抗炎作用，在大鼠腹泻诱导的慢性关节炎模型。HP-ext剂量依赖性地抑制小鼠巨噬细胞中脂多糖（LPS）诱导的炎性细胞因子[白介素-1 β（IL-1 β）、白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）]的产生（RAW 264.7）。哈巴俄苷是魔鬼爪中存在的主要环烯醚萜苷，被发现是HP-ext中的活性剂之一，并通过RAW 264.7抑制IL-1 β、IL-6和TNF-α的产生。
Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced production of inflammatory cytokines [interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] in mouse macrophage cells (RAW 264.7). Harpagoside, a major iridoid glycoside present in devil's claw, was found to be one of the active agents in HP-ext and inhibited the production of IL-1 beta, IL-6, and TNF-alpha by RAW 264.7.