High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV
High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV
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高水平的IL-27与Th17细胞呈正相关可能表明HBV感染者存在肝损伤。
DOI：
10.1111/liv.12268
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发表时间：
2014-02-01
影响因子：
6.7
通讯作者：
Gao, Zhi-Liang
中科院分区：
文献类型：
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作者：
Zhang, Geng-Lin;Xie, Dong-Ying;Gao, Zhi-Liang
研究背景白细胞介素6/白细胞介素12家族细胞因子通过影响辅助性T细胞的分化或调节在炎症性疾病中发挥关键作用。受试者和23名慢性加急性肝功能衰竭（ACLF）受试者]和18名正常对照（NC）。采用酶联免疫吸附法检测血清IL-27水平。结果HBV感染者血清IL-27水平（502.88 ± 23.35pg/ml）明显高于正常对照组（277.14 ± 23.96pg/ml，P
BackgroundInterleukin-6/IL-12 family cytokines play a key role in inflammatory diseases via their effects on the differentiation or regulation of T helper cells.AimsThe aim of this study was to determine the role of interleukin-27 (IL-27) and its association with helper T cells in hepatitis B virus (HBV)-infected patients.MethodsSamples were assessed from 51 HBV-infected patients [28 chronic hepatitis B (CHB) subjects and 23 acute-on-chronic liver failure (ACLF) subjects] and 18 normal controls (NC). Serum IL-27 levels were examined by enzyme-linked immunosorbent assay. Circulating helper T cells were determined using flow cytometry and associations between IL-27 expression and helper T cells were analysed.ResultsSerum IL-27 levels rose in HBV-infected patients (502.8823.35pg/ml) compared to (NC, 277.14 +/- 23.96pg/ml, P