Coordination-responsive drug release inside gold nanorod@metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy
Coordination-responsive drug release inside gold nanorod@metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy
复制标题
金纳米棒@金属有机框架核壳纳米结构内的配位响应药物释放，用于近红外诱导的协同化学光热治疗
DOI：
10.1007/s12274-017-1874-y
复制
发表时间：
2018-06-01
期刊：
影响因子：
9.9
通讯作者：
Tang, Zhiyong
中科院分区：
文献类型：
--
作者：
Li, Yantao;Jin, Jun;Tang, Zhiyong
近年来，由不同组分集成而成的多功能核壳纳米结构作为一种很有前途的生物平台受到了广泛的关注。本工作将晶态分子筛咪唑骨架-8(ZIF-8)这种典型的金属-有机骨架(MOF)包覆在单根金纳米棒(AuNR)核上，成功地实现了近红外光引发的协同光热和化学治疗。令人印象深刻的是，高载药量的阿霉素(DOX)随后通过体系中配位键的形成和断裂，可以很容易地实现pH和近红外双刺激响应的DOX释放。此外，在808 nm的近红外激光照射下，这些新型的AuNR@MOF核壳纳米结构在体外和体内都显示出有效的协同化学光热治疗，通过静脉注射的细胞治疗和肿瘤消融证实了这一点。
Multifunctional core-shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms in recent years. In this work, crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single gold nanorod(AuNR) core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared (NIR) light. Impressively, high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under NIR laser irradiation at 808 nm, these novel AuNR@MOF core-shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation via intravenous injection.