Not one extrastriate body area: using anatomical landmarks, hMT+, and visual field maps to parcellate limb-selective activations in human lateral occipitotemporal cortex.
Not one extrastriate body area: using anatomical landmarks, hMT+, and visual field maps to parcellate limb-selective activations in human lateral occipitotemporal cortex.
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DOI：
10.1016/j.neuroimage.2011.03.041
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发表时间：
2011-06-15
期刊：
影响因子：
5.7
通讯作者：
Grill-Spector, Kalanit
中科院分区：
文献类型：
--
作者：
Weiner, Kevin S.;Grill-Spector, Kalanit
人类外侧枕颞叶皮层（LOTC）组织的流行观点表明，一个单一的区域选择性的图像的人体（外纹体区，EBA），高度重叠的人类运动选择性复合体（hMT+）。使用比过去的研究（3- 4 mm体素）更高分辨率（1.5mm体素）的功能磁共振成像，我们检查了这些激活相对于彼此的精细尺度空间组织，以及LOTC中的视野图。不是一个连续的EBA高度重叠的hMT+，结果表明在hMT+周围的新月中组织的三个肢体选择性激活：（1）在hMT+之后，在外侧枕沟/中枕回（LOS/MOG）上的激活与视野图LO-2和TO-1之间共享的下垂直子午线重叠，（2）颞中回（MTG）上hMT+之前的激活始终与TO-2的下垂直子午线重叠并延伸到目前定义的视野图之外，（3）颞下回（ITG）上的激活低于hMT+，与TO簇的脑旁代表重叠。这种围绕hMT+的肢体选择性激活的新月形组织在三年内是可重复的，并且在用于定位的不同图像类型中是一致的。此外，这些区域表现出不同的位置属性：对侧图像呈现的偏好减少，中央凹呈现的偏好增加，从肢体选择性LOS到MTG。最后，肢体选择性激活和视野图之间的关系延伸到背侧流，其中后部IPS激活与V7重叠。总的来说，我们的测量结果证明了一系列LOTC肢体选择性激活，1）具有单独的解剖和功能边界，2）重叠不同的视野图，3）说明了不同的位置属性。这些发现表明，类别选择性本身是一个不充分的组织原则来定义大脑区域。相反，为了包裹和理解高级视觉皮层的功能组织，需要多个属性。
The prevailing view of human lateral occipitotemporal cortex (LOTC) organization suggests a single area selective for images of the human body (extrastriate body area, EBA) that highly overlaps with the human motion-selective complex (hMT+). Using functional magnetic resonance imaging with higher resolution (1.5mm voxels) than past studies (3–4mm voxels), we examined the fine-scale spatial organization of these activations relative to each other, as well as to visual field maps in LOTC. Rather than one contiguous EBA highly overlapping hMT+, results indicate three limb-selective activations organized in a crescent surrounding hMT+: (1) an activation posterior to hMT+ on the lateral occipital sulcus/middle occipital gyrus (LOS/MOG) overlapping the lower vertical meridian shared between visual field maps LO-2 and TO-1, (2) an activation anterior to hMT+ on the middle temporal gyrus (MTG) consistently overlapping the lower vertical meridian of TO-2 and extending outside presently defined visual field maps, and (3) an activation inferior to hMT+ on the inferotemporal gyrus (ITG) overlapping the parafoveal representation of the TO cluster. This crescent organization of limb-selective activations surrounding hMT+ is reproducible over a span of three years and is consistent across different image types used for localization. Further, these regions exhibit differential position properties: preference for contralateral image presentation decreases and preference for foveal presentation increases from the limb-selective LOS to the MTG. Finally, the relationship between limb-selective activations and visual field maps extends to the dorsal stream where a posterior IPS activation overlaps V7. Overall, our measurements demonstrate a series of LOTC limb-selective activations that 1) have separate anatomical and functional boundaries, 2) overlap distinct visual field maps, and 3) illustrate differential position properties. These findings indicate that category selectivity alone is an insufficient organization principle for defining brain areas. Instead, multiple properties are necessary in order to parcellate and understand the functional organization of high-level visual cortex.
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DOI：
10.1073/pnas.0500003102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Dougherty, RF;Ben-Shachar, M;Wandell, BA
通讯作者：
Wandell, BA
影响因子：
5.3
作者：
Downing, Paul E.;Wiggett, Alison J.;Peelen, Marius V.
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Peelen, Marius V.
影响因子：
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作者：
BOUSSAOUD, D;DESIMONE, R;UNGERLEIDER, LG
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UNGERLEIDER, LG
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
影响因子：
3.7
作者：
Dumoulin, SO;Bittar, RG;Evans, AC
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Evans, AC