Food anticipation and subsequent food withdrawal increase serum cortisol in healthy men
Food anticipation and subsequent food withdrawal increase serum cortisol in healthy men
复制标题
DOI：
10.1016/j.physbeh.2011.04.020
复制
发表时间：
2011-07-06
影响因子：
2.9
通讯作者：
Hallschmid, Manfred
中科院分区：
文献类型：
--
作者：
Ott, Volker;Friedrich, Monique;Hallschmid, Manfred
对食物摄入的预期包括内分泌变化，根据动物实验，内分泌变化包括HPA轴活动的上升。在人类中，HPA轴对食物预期和戒断的反应，尽管具有临床意义，但尚未得到彻底的研究。我们评估了神经内分泌和心理影响的食物预期和扣留预期的食物在健康的人类受试者。食物预期诱导14名男子在0800小时的公告和随后介绍的自助早餐。令人惊讶的是，在组织问题的借口下，预期的膳食在1000小时被扣留。在0800 h时告知15名禁食对照，他们将在整个实验期间保持禁食。在这两组中，饥饿，情绪和循环浓度的葡萄糖，胰岛素，皮质醇，促肾上腺皮质激素，瘦素和ghrelin进行了评估。中午12时。所有受试者都被允许从一盘饼干中进食。与无预期相比，食物预期与血清皮质醇水平的相对增加、血糖的急剧下降和自我饥饿感的增加有关。当预期的食物被扣留，自测情绪恶化，皮质醇水平仍然升高，而血糖水平下降，延迟50分钟。其他内分泌参数和饼干摄入量组之间是可比的。我们的研究结果表明，食物预期没有随后的食物奖励增加皮质醇水平，降低血糖的可用性。他们支持这样的假设，即饮食限制，与习惯性延长预期的食物，暂时被扣留的时间，可能有助于对HPA轴活动的有害影响超重的发展。(C)2011 Elsevier Inc. All rights reserved.
The anticipation of food intake comprises endocrine changes that according to animal experiments include a rise in HPA axis activity. In humans, HPA axis responses to food anticipation and withdrawal, although of clinical relevance, have not been thoroughly examined. We assessed neuroendocrine and psychological effects of food anticipation and of withholding anticipated food in healthy human subjects. Food anticipation was induced in 14 men at 0800 h by the announcement and subsequent presentation of a breakfast buffet. The expected meal was surprisingly withheld at 1000 h under the pretense of an organizational problem. Fifteen fasted controls were informed at 0800 h that they would remain fasted throughout the experiments. In both groups, hunger, mood and circulating concentrations of glucose, insulin, cortisol, ACTH, leptin and ghrelin were assessed. At 1200 h. all subjects were allowed to eat from a plate of cookies. Compared to non-anticipation, food anticipation was associated with a relative increase in serum cortisol levels, an acute drop in plasma glucose and increased self-rated hunger. When anticipated food was withheld, self-rated mood deteriorated and cortisol levels remained elevated, while plasma glucose levels decreased with a delay of 50 min. Other endocrine parameters and cookie intake were comparable between groups. Our results indicate that food anticipation without subsequent food reward increases cortisol levels and reduces blood glucose availability. They support the assumption that dietary restraint, being associated with habitually extended periods of anticipating food that is temporarily withheld, may contribute to the development of overweight by detrimental effects on HPA-axis activity. (C) 2011 Elsevier Inc. All rights reserved.