One month survival with the undulation pump total artificial heart in a goat.
One month survival with the undulation pump total artificial heart in a goat.
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使用波动泵全人工心脏的山羊存活一个月。
DOI：
10.1111/j.1525-1594.2001.6655-5.x
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发表时间：
2001
影响因子：
2.4
通讯作者：
K. Imachi
中科院分区：
文献类型：
--
作者：
Y. Abe;T. Chinzei;T. Isoyama;T. Ono;S. Mochizuki;I. Saito;K. Iwasaki;M. Ishimaru;T. Karita;A. Kuono;K. Baba;K. Imachi
波动泵是一种小型连续流容积式血泵。波动泵全人工心脏（UPTAH）是一种独特的采用波动泵的植入式全人工心脏。使用体重45.8公斤的成年雌性山羊进行植入。在体外循环下用UPTAH替代自然心脏。通过手动控制右侧泵将心输出量 (CO) 维持在 100 ml/kg/min。为防止肺水肿，自动控制左泵，将左心房压力维持在20毫米汞柱以下。 CO维持2周。此后，CO逐渐减少。术后第31天，这只山羊因脑中风突然死亡。尸检时，左心房袖腔几乎被巨大的血管翳样血栓占据，这被认为是死因。心房袖的改进对于获得更长的生存期是必要的，并且正在被修改。泵内未发现血栓。然而，左侧电机的温度升高是一个问题。提高电机的效率是必要的。尽管仍然存在许多问题，但使用这种独特的使用连续流置换型血泵的植入式 TAH 可以获得 1 个月的生存期。
The undulation pump is a small continuous flow displacement-type blood pump. The undulation pump total artificial heart (UPTAH) is a unique implantable total artificial heart using undulation pumps. An adult female goat weighing 45.8 kg was used for implantation. The natural heart was replaced with the UPTAH under extracorporal circulation. The cardiac output (CO) was maintained to 100 ml/kg/min by controlling the right pump manually. To prevent lung edema, the left pump was controlled automatically to maintain the left atrial pressure below 20 mm Hg. The CO was maintained for 2 weeks. Thereafter, the CO gradually decreased. The goat suddenly died because of a brain stroke on the 31st postoperative day. At autopsy, the cavity of the left atrial cuff was almost occupied by the big pannus-like thrombus, which was thought to be the cause of death. Improvement of the atrial cuff is necessary to obtain longer survival and is being modified. No thrombus was found inside the pumps. However, temperature rise in a left motor was a problem. Improvement of the efficiency in a motor is necessary. Although many problems still remained, 1 month survival could be obtained with this unique implantable TAH using continuous flow displacement-type blood pumps.