Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, or acetaminophen and risk of ovarian cancer.
Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, or acetaminophen and risk of ovarian cancer.
复制标题
DOI：
10.1097/ede.0b013e3182456ad3
复制
发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Ness RB
中科院分区：
文献类型：
--
作者：
Lo-Ciganic WH;Zgibor JC;Bunker CH;Moysich KB;Edwards RP;Ness RB
阿司匹林，非阿司匹林非甾体抗炎药（NA-NSAIDs）和对乙酰氨基酚都有生物学作用，可能会降低卵巢癌的风险。然而，关于这个问题的流行病学数据是混合的。在宾夕法尼亚州西部、俄亥俄州东部和纽约州西部进行的一项基于人群的病例对照研究纳入了902名在2003年2月至2008年11月期间诊断为偶发性上皮性卵巢癌的妇女和1,802名匹配的对照。通过面对面访谈评估在参考日期（访谈日期前9个月）之前定期使用（每周至少2片，持续6个月或更长时间）阿司匹林、NA-NSAID和对乙酰氨基酚的情况。我们使用逻辑回归计算调整后的比值比（OR）和95%置信区间（CI）。阿司匹林使用的OR为0.81（95% CI= 0.63-1.03）。在连续服用阿司匹林的妇女中发现风险降低（0.71 [0.54-0.94]）或低标准化日剂量（0.72 [0.53-0.97]），使用阿司匹林预防心血管疾病（0.72 [0.57-0.97]）、最近使用阿司匹林或使用选择性考克斯-2抑制剂的患者（0.60 [0.39-0.94]）。在使用非选择性NA-NSAID或对乙酰氨基酚的女性中未观察到相关性。使用阿司匹林或选择性考克斯-2抑制剂可降低卵巢癌的风险。然而，由于固有的研究局限性和偏倚，应谨慎解释结果。
Aspirin, non-aspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) and acetaminophen all have biologic effects that might reduce the risk of ovarian cancer. However, epidemiologic data on this question are mixed. A population-based, case-control study in western Pennsylvania, eastern Ohio, and western New York State included 902 women with incident epithelial ovarian cancer who were diagnosed between February 2003 to November 2008 and 1,802 matched controls. Regular use (at least 2 tablets per week for 6 months or more) of aspirin, NA-NSAIDs, and acetaminophen before the reference date (9 months before interview date) was assessed by in-person interview. We used logistic regression to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). The OR for aspirin use was 0.81 (95% CI= 0.63–1.03). Decreased risks were found among women who used aspirin continuously (0.71 [0.54–0.94]) or at a low-standardized daily dose (0.72 [0.53–0.97]), who used aspirin for the prevention of cardiovascular disease (0.72 [0.57–0.97]), who used aspirin more recently, or who used selective COX-2 inhibitors (0.60 [0.39–0.94]). No associations were observed among women using non-selective NA-NSAIDs or acetaminophen. Risk reductions of ovarian cancer were observed with use of aspirin or selective COX-2 inhibitors. However, the results should be interpreted with caution due to the inherent study limitations and biases.