Family history of gynaecological cancers: relationships to the incidence of breast cancer prior to age 55.
Family history of gynaecological cancers: relationships to the incidence of breast cancer prior to age 55.
复制标题
妇科癌症家族史：与 55 岁之前乳腺癌发病率的关系。
DOI：
10.1093/ije/20.3.595
复制
发表时间：
1991
影响因子：
7.7
通讯作者：
Schildkraut,JM
中科院分区：
文献类型：
--
作者：
Thompson,WD;Schildkraut,JM
作为20 - 54岁妇女癌症多中心流行病学研究的一部分，收集了4730名新诊断乳腺癌妇女的女性亲属和4688名普通妇女亲属的妇科癌症家族史数据。在45岁之前被诊断患有乳腺癌的女性比对照组更有可能有母亲或姐妹患有卵巢癌（比值比（OR）：1.50），子宫内膜癌（1.29）和宫颈癌（1.53），尽管这些升高都没有达到统计学意义。45岁至54岁之间被诊断患有乳腺癌的女性的相应比值比为1.88，0.84和0.93。该组与卵巢癌的相关性具有统计学意义（95%置信区间（CI）：1.11-3.19）。在后一组中，一级亲属患卵巢癌与乳腺癌的相关性与一级亲属患乳腺癌的相关性大致相同。研究结果表明，乳腺癌和卵巢癌可能有共同的遗传基础。从临床的角度来看，结果表明，在设置适当的乳腺癌筛查水平，并在建立一个适当的年龄，开始这样的筛查为特定的妇女，她的卵巢癌家族史应考虑除了她的乳腺癌家族史。
As part of a multi-centre epidemiological study of cancer in women between the ages of 20 and 54, data were collected concerning family history of gynaecological cancers in the female relatives of 4730 women with newly diagnosed breast cancer and the relatives of 4688 women from the general population. Women who were diagnosed with breast cancer prior to age 45 were more likely than controls to have a mother or sister with ovarian cancer (odds ratio (OR): 1.50), endometrial cancer (1.29), and cervical cancer (1.53), although none of these elevations achieved statistical significance. The corresponding odds ratios for women diagnosed with breast cancer between the ages of 45 and 54 were 1.88, 0.84 and 0.93. The association with ovarian cancer was statistically significant in this group (95% confidence interval (CI): 1.11–3.19). In this latter group, having a first degree relative with ovarian cancer was associated approximately as strongly with breast cancer as was having a first degree relative with breast cancer. The results suggest that there may be a shared genetic basis for some cancers of the breast and ovary. From a clinical perspective, the results indicate that in setting appropriate levels of screening for breast cancer and in establishing an appropriate age at which to begin such screening for a particular woman, her family history of ovarian cancer should be considered in addition to her family history of breast cancer.