Pharmacological Effect of Beta Toxin of Clostridium perfringens Type C on Rats
Pharmacological Effect of Beta Toxin of Clostridium perfringens Type C on Rats
复制标题
C型产气荚膜梭菌β毒素对大鼠的药理作用
DOI：
10.1111/j.1348-0421.1981.tb00045.x
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发表时间：
1981
影响因子：
2.6
通讯作者：
K. Endo
中科院分区：
文献类型：
--
作者：
J. Sakùrai;Y. Fujii;M. Matsuura;K. Endo
研究了产气荚膜梭菌C型纯化β毒素在体内的生物学效应。在给大鼠静脉注射纯化的β毒素后，观察到血压升高，同时心率下降。血压达到最高值后，心率逐渐恢复，心电图和呼吸开始改变。毒素引起的血压升高往往与毒素的量成正比。随着毒素浓度的增加，注射毒素与发病之间的潜伏期增加，以及注射毒素与毒素引起的最大压力之间的时间缩短。研究发现，导致血压升高的因素与β毒素之间存在良好的相关性。肾上腺素能和神经节阻滞剂可降低β毒素引起的血压升高。数据表明，这种毒素导致儿茶酚胺的释放，而血压的升高是由释放的儿茶酚胺引起的。
The biological effect of purified beta toxin of Clostridium perfringens type C in vivo was investigated. After intravenous injection of the purified beta toxin into rats, a rise in blood pressure and a simultaneous fall in heart rate were observed. After the blood pressure reached a maximum, the heart rate recovered gradually, and electrocardiographic and respiratory changes began. The rise in blood pressure induced by beta toxin tended to be proportional to the amount of toxin. The latent period between the injection of toxin and the onset of the increase, and also the time between the injection and the maximum pressure induced by the toxin decreased with increasing concentration of the toxin. A good correlation was found between the factor producing the rise in blood pressure and beta toxin. Alpha adrenergic and ganglionic blocking agents reduced blood pressure levels elevated by beta toxin. The data suggest that the toxin causes a release of catecholamines, and that the increase in blood pressure was induced by released catecholamines.