Urinary desmosine is associated with emphysema severity and frequent exacerbation in patients with COPD
Urinary desmosine is associated with emphysema severity and frequent exacerbation in patients with COPD
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DOI：
10.1111/resp.13170
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发表时间：
2018-02-01
期刊：
影响因子：
6.9
通讯作者：
Park, Yong Bum
中科院分区：
文献类型：
--
作者：
Kim, Changhwan;Ko, Yousang;Park, Yong Bum
背景与目的基质降解是慢性阻塞性肺疾病（COPD）的重要特征.锁链素和异锁链素（锁链素）在基质降解后经尿液排泄。本研究的主要目的是探讨计算机断层扫描（CT）肺气肿指数和尿桥索蛋白在COPD patients.MethodsA共152例受试者之间的关联被选中从韩国阻塞性肺疾病队列。采用液相色谱-串联质谱（LC-MS/MS）法测定其尿液中锁链素的含量。根据CT肺气肿指数将队列分为肺气肿显性（n=80）和非肺气肿显性（n=72）组。两组之间的体重指数和肺功能也存在显著差异。多因素分析表明，高水平的尿锁链素是肺气肿的一个重要的独立预测因子（相对危险度：2.6; 95%CI：1.11-6.09; P=0.028）。在随访的第一年，高尿锁链素组中频繁加重者的百分比显著较高（P=0.041）。高尿锁链素组的平均急性加重次数较高，尽管该差异无统计学显著性（P=0.067）。肺气肿指数的变化并没有显着差异两个尿锁链素组超过3 years的follow-up.ConclusionThis研究表明，水平的尿锁链素测定LC-MS/MS方法与CT肺气肿指数。尿锁链素可以作为一个有用的预测因子，在确定频繁的accelerator.Previous研究揭示了不一致的肺气肿的严重程度和锁链素之间的关联释放由于基质降解在慢性阻塞性肺疾病（COPD）。这项研究表明，尿锁链素，液相色谱-串联质谱（LC-MS/MS）方法测量，是有用的预测肺气肿的严重程度和频繁加重的COPD患者。
Background and objectiveMatrix degradation is a key feature of chronic obstructive pulmonary disease (COPD). Desmosine and isodesmosine (desmosines) are excreted in urine following matrix degradation. The main purpose of this study was to investigate the association between computed tomography (CT) emphysema indices and urinary desmosines in patients with COPD.MethodsA total of 152 subjects were selected from the Korean Obstructive Lung Disease cohort. Their urine samples were assayed for desmosines using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. The cohort was divided into emphysema-dominant (n=80) and non-emphysema dominant- (n=72) groups according to the CT emphysema index.ResultsThe level of urinary desmosines was significantly higher in the emphysema-dominant group. Significant differences were also observed between the two groups for body mass index and lung function. Multivariate analysis indicated that a high level of urinary desmosines was a significant independent predictor of emphysema (relative risk: 2.6; 95% CI: 1.11-6.09; P=0.028). The percentage of frequent exacerbators was significantly higher in the high urinary desmosine group in the first year of follow-up (P=0.041). The mean number of exacerbations was higher in the high urinary desmosine group, although this difference was not statistically significant (P=0.067). The changes in emphysema index did not differ between the two urinary desmosine groups over 3years of follow-up.ConclusionThis study indicates that the level of urinary desmosines measured by LC-MS/MS methods is associated with the CT emphysema index. Urinary desmosine can be a useful predictor in identifying frequent exacerbators.Previous studies have revealed inconsistencies as to the association between emphysema severity and desmosines released due to matrix degradation in chronic obstructive pulmonary disease (COPD). This study suggests that urinary desmosines, measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods, are useful for predicting emphysema severity and frequent exacerbation in patients with COPD.