Effects of periodic leg movements during sleep in middle-aged subjects without sleep complaints
Effects of periodic leg movements during sleep in middle-aged subjects without sleep complaints
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DOI：
10.1002/mds.20506
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发表时间：
2005-09-01
影响因子：
8.6
通讯作者：
Morettini, J
中科院分区：
文献类型：
--
作者：
Carrier, J;Frenette, S;Morettini, J
最近的报告对陡峭障碍（PLMSD）期间周期性腿部运动作为特定临床实体的相关性提出了质疑。由于周期性腿部运动陡峭指数（PLMSI）随着年龄的增长而增加，因此它已成为衰老研究中的重要排除标准。然而。对于没有睡眠问题的中年受试者，PLMSI 是否与睡眠质量相关尚不清楚。对 70 名没有睡眠问题的健康中年受试者（40 至 60 岁）的睡眠进行了评估。根据 PLMSI 严重程度将受试者分为两组：(1) 43 名受试者（28 名女性，15 名男性）属于低 PLMSI 组 (10)。 PLMSI 大于 5 的男性比例显着高于女性。PLMSI 严重程度组对多导睡眠图睡眠参数没有显着影响。 PLMSI 对主观睡眠质量产生微小但显着的影响，尤其是对中年男性。这些结果提出了关于 PLMSI 作为无睡眠问题的中年受试者病理指标的相关性的问题，并支持这样的观点，即 PLMSI 的增加可能是与多巴胺能功能丧失相关的正常衰老过程的一部分。 (C) 2005 年运动障碍协会。
Recent reports have called into question the relevance of periodic leg movements during steep disorder (PLMSD) as a specific clinical entity. Because periodic leg movement in steep index (PLMSI) increases with age, it has become an important exclusion criterion in research on aging. However. it is unknown if PLMSI is related to sleep quality in middle-aged subjects without sleep complaints. The sleep of 70 healthy, middle-aged subjects (age 40 to 60 years) without sleep complaints was evaluated. Subjects were divided into two groups according to their PLMSI severity: (1) 43 subjects (28 women. 15 men) were in the low PLMSI group (10). A significantly higher proportion of men than women showed PLMSI greater than 5. There was no significant effect of PLMSI severity group for polysomnographic sleep parameters. PLMSI exerted a small but significant effect on subjective sleep quality, especially in middle-aged men. These results raise questions about the relevance of PLMSI as a pathological index for middle-aged subjects without sleep complaints and support the notion that an increase in PLMSI may be part of the normal process of aging associated with the loss of dopaminergic function. (C) 2005 Movement Disorder Society.