Immunology of Endometriosis
Immunology of Endometriosis
复制标题
DOI：
10.1097/grf.0b013e3181db7c33
复制
发表时间：
2010-06-01
影响因子：
1.5
通讯作者：
Barrier, Breton F.
中科院分区：
文献类型：
--
作者：
Barrier, Breton F.
子宫内膜异位症是一种常见的疾病，具有不同的表型。症状性病例与异位和在位子宫内膜中的孕酮抵抗和失调的细胞因子产生有关。至少在某些情况下，这似乎与慢性局部炎症和抗体自身反应有关。子宫内膜异位症与自身免疫性疾病的共存已被记录在少数病例中，并且一些子宫内膜异位症患者的血清中存在自身反应性抗体是常见的报道。本文简要回顾了子宫内膜异位症和自身免疫性疾病之间的关系，并描述了炎症在这些患者免疫自身反应性发展中的潜在作用。
Endometriosis is a common condition with a varied phenotype. Symptomatic cases have been associated with progesterone resistance and dysregulated cytokine production in both ectopic and eutopic endometrium. In at least some cases, this seems to be associated with chronic local inflammation and antibody self-reactivity. Coexistence of endometriosis with autoimmune disease has been documented in a small number of cases, and the presence of autoreactive antibodies in the serum of some patients with endometriosis is commonly reported. This paper briefly reviews the association between endometriosis and autoimmune disease and describes the potential role of inflammation in the development of immunologic self-reactivity in these patients.