Enhancement of antimicrobial activity by synthetic ion channel synergy
Enhancement of antimicrobial activity by synthetic ion channel synergy
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DOI：
10.1039/c0cc03138k
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Gokel, George W.
中科院分区：
文献类型：
--
作者：
Atkins, Jason L.;Patel, Mohit B.;Gokel, George W.
研究发现，当红霉素、卡那霉素、利福平和四环素与通道亚致死浓度的抗生素共同给药时，亲水性合成离子通道可增强对大肠杆菌和枯草芽孢杆菌的细胞毒性。
Hydraphile synthetic ion channels were found to enhance the cytotoxicity to E. coli and B. subtilis of erythromycin, kanamycin, rifampicin, and tetracycline when co-administered with the antibiotic at sublethal concentrations of channel.