The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period: an EEG-fMRI study
The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period: an EEG-fMRI study
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DOI：
10.1093/sleep/zsy056
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发表时间：
2018-06-01
期刊：
影响因子：
5.6
通讯作者：
Wu, Yu-Zu
中科院分区：
文献类型：
--
作者：
Hsiao, Fan-Chi;Tsai, Pei-Jung;Wu, Yu-Zu
睡眠的主观感知不一定与脑电图（EEG）所显示的睡眠迹象相符。主观报告和客观测量之间的不匹配通常被称为“睡眠状态感知错误”。先前的研究表明，这种不匹配在失眠患者和正常睡眠者中均存在，但神经生理机制仍不清楚。本研究的目的是从脑电图功率和功能磁共振成像（fMRI）波动的角度探索这种机制的神经生理基础。36名健康的年轻成年人参与了研究。参与者在晚上约9点在磁共振成像扫描仪中尝试入睡时，同时进行脑电图和功能磁共振成像记录。他们在进入稳定的N1或N2睡眠阶段后，或者在90分钟内未进入稳定睡眠时被唤醒。然后，他们被要求回忆在醒来前一刻的意识体验。共收集到61次预定唤醒情况：其中21次是在进入稳定的N2睡眠阶段之后；12次在N1睡眠阶段；20次在清醒状态。与那些没有主客观差异的唤醒情况（n = 27）相比，有差异的唤醒情况（n = 14）与较低的功率以及较高的α、β和γ功率相关。此外，我们发现，与没有差异的参与者相比，表现出差异的参与者在前额叶皮质中显示出更高幅度的低频波动水平。这些结果支持了主客观差异与中枢神经系统过度兴奋有关的推测。
Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports and objective measures is often referred to as "sleep state misperception." Previous studies evince that this mismatch is found in both patients with insomnia and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and functional magnetic resonance imaging (fMRI) fluctuations. Thirty-six healthy young adults participated in the study. Simultaneous EEG and fMRI recordings were conducted while the participants were trying to fall asleep in an MRI scanner at approximately 9: 00 pm. They were awakened after achieving stable N1 or N2 sleep, or after 90 min without falling into stable sleep. Next they were asked to recall their conscious experiences from the moment immediately prior to awakening. Sixty-one instances of scheduled awakenings were collected: 21 of these after having achieved stable stage N2 sleep; 12, during stage N1 sleep; and, 20 during the waking state. Relative to those awakenings without subjective-objective discrepancy (n = 27), these awakenings with discrepancy (n = 14) were associated with lower. power, as well as higher alpha, beta, and gamma power. Moreover, we found that participants who exhibited the discrepancy, compared with those who did not, evinced a higher amplitude of low-frequency fluctuation levels in the prefrontal cortex. These results lend support to the conjecture that the subjective-objective discrepancy is associated with central nervous system hyperarousal.