How methionine and glutamine prevent inhibition of growth by methionine sulfoximine.

How methionine and glutamine prevent inhibition of growth by methionine sulfoximine.
复制标题

DOI:
10.1016/0005-2736(72)90146-0
复制
发表时间:
1972-04
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
F. Meins;Marc L. Abrams
F. Meins;Marc L. Abrams
中科院分区:
其他
文献类型:
--
作者:
F. Meins;Marc L. Abrams

文献摘要

被引文献

相似文献

甲硫氨酸亚砜胺是一种有效的谷氨酰胺合成酶抑制剂,能抑制寻常小球藻的生长。在生长培养基中加入l -谷氨酰胺或l -蛋氨酸可以防止生长抑制。我们表明谷氨酰胺和蛋氨酸通过阻断蛋氨酸亚砜胺进入细胞而起作用。
Methionine sulfoximine, a potent inhibitor of glutamine synthetase, inhibits growth ofChlorella vulgaris. Growth inhibition is prevented by adding L-glutamine or L-methionine to the growth medium. We show that glutamine and methionine act by blocking methionine sulfoximine uptake into the cell.