Meprin α and meprin β: Procollagen proteinases in health and disease
Meprin α and meprin β: Procollagen proteinases in health and disease
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DOI：
10.1016/j.matbio.2015.01.010
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发表时间：
2015-05-01
期刊：
影响因子：
6.9
通讯作者：
Becker-Pauly, Christoph
中科院分区：
文献类型：
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作者：
Prox, Johannes;Arnold, Philipp;Becker-Pauly, Christoph
金属蛋白酶meprin α和meprin β是最近发现的前胶原蛋白酶，能够切断I型和III型纤维性胶原的球形C端和n端原结构域。这种蛋白水解过程确实足以诱导胶原纤维的组装，如透射电子显微镜所见。在meprin α和meprin β敲除小鼠的帮助下，生物学相关性得到了证明，这些小鼠表现出皮肤胶原沉积减少，导致抗拉强度受损。另一方面，meprin金属蛋白酶在皮肤（瘢痕疙瘩）和肺（肺动脉高压）的纤维化条件下过度表达。因此，通过特异性抑制来调节meprin活性以减少胶原成熟可能是治疗某些病理条件的合适方法。(C) 2015 Elsevier B.V.
Metalloproteases meprin alpha and meprin beta were recently discovered as procollagen proteinases, capable of cleaving off the globular C- and N-terminal prodomains of fibrillar collagen type I and type III. This proteolytic process is indeed sufficient to induce collagen fibril assembly as visualized by transmission electron microscopy. The biological relevance was demonstrated with the help of meprin alpha and meprin beta knock-out mice, which exhibit decreased collagen deposition in skin resulting in impaired tensile strength. On the other hand, overexpression of meprin metalloproteases was found under fibrotic conditions in the skin (keloids) and the lung (pulmonary hypertension). Thus, regulation of meprin activity by specific inhibition to reduce collagen maturation might be a suitable approach for the treatment of certain pathological conditions. (C) 2015 Elsevier B.V.