Analysis in early stage triple-negative breast cancer treated with mastectomy without adjuvant radiotherapy: Patterns of failure and prognostic factors
Analysis in early stage triple-negative breast cancer treated with mastectomy without adjuvant radiotherapy: Patterns of failure and prognostic factors
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DOI：
10.1002/cncr.28085
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发表时间：
2013-07-01
期刊：
影响因子：
6.2
通讯作者：
Feng, Yan
中科院分区：
文献类型：
--
作者：
Chen, Xingxing;Yu, Xiaoli;Feng, Yan
本研究的目的是评估和确定局部复发（LRR）的失败模式和预后因素，这些因素可以证明早期三阴性乳腺癌患者改良根治术后乳房切除术后放疗的合理性。方法2000年1月至2007年7月，作者回顾性分析了390例三阴性乳腺癌患者，T1/T2肿瘤和0至3个阳性淋巴结（病理T1-T2 N 0-N1），在作者的机构接受了改良根治术，没有乳房切除术后放疗。使用Kaplan-Meier分析计算事件的5年累积发生率，使用对数秩检验比较亚组。采用考克斯比例风险模型进行多变量分析。结果总体而言，86.4%的患者接受了化疗。中位随访60.5个月时，5年累积局部复发率、区域复发率、LRR和远处转移率分别为5.4%、4.7%、8%和13.4%。在多变量分析中，年龄
BACKGROUND The objective of this study was to evaluate and identify patterns of failure and prognostic factors for locoregional recurrence (LRR) that could justify postmastectomy radiotherapy after modified radical mastectomy in patients with early stage triple-negative breast cancer. METHODS Between January 2000 and July 2007, the authors retrospectively analyzed 390 patients who had triple-negative breast cancer with T1/T2 tumors and from zero to 3 positive lymph nodes (pathologic T1-T2N0-N1) who underwent modified radical mastectomy without postmastectomy radiotherapy at the author's institution. The 5-year cumulative incidence for events was calculated using Kaplan-Meier analysis, and subgroups were compared using the log-rank test. Multivariate analysis was performed using a Cox proportional hazards model. RESULTS Overall, 86.4% of patients received chemotherapy. At a median follow-up of 60.5 months, the 5-year cumulative rates of local recurrence, regional recurrence, LRR, and distant metastasis were 5.4%, 4.7%, 8%, and 13.4%, respectively. On multivariate analysis, age