Presynaptic modulation by somatostatin in the neostriatum
Presynaptic modulation by somatostatin in the neostriatum
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DOI：
10.1007/s11064-007-9579-3
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发表时间：
2008-08-01
影响因子：
4.4
通讯作者：
Galarraga, Elvira
中科院分区：
文献类型：
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作者：
Gisselle Lopez-Huerta, Violeta;Tecuapetla, Fatuel;Galarraga, Elvira
中棘投射神经元（MSNs）是新纹状体的主要神经元群体。MSN具有抑制性和GABA能。MSN通过产生侧抑制的局部轴突侧支与其他MSN连接，这被认为是选择运动动作的细胞组件。MSN还接收来自GABA能局部中间神经元的抑制性输入。这项工作表明，通过使用成对脉冲协议，生长抑素（SST）的行为突触前调节GABA释放的终端互连MSN。这种SST作用是可逆的，不通过多巴胺的释放介导。它被SST受体（SSTR）拮抗剂环索他汀（cicloSST）阻断。相反，SST不调节来自中间神经元的抑制。由于SST是由一类局部中间神经元释放的，因此可以得出结论，该神经元有助于调节运动行为的选择。
Medium spiny projection neurons (MSNs) are the main neuronal population in the neostriatum. MSNs are inhibitory and GABAergic. MSNs connect with other MSNs via local axon collaterals that produce lateral inhibition, which is thought to select cell assemblies for motor action. MSNs also receive inhibitory inputs from GABAergic local interneurons. This work shows, through the use of the paired pulse protocol, that somatostatin (SST) acts presynaptically to regulate GABA release from the terminals interconnecting MSNs. This SST action is reversible and not mediated through the release of dopamine. It is blocked by the SST receptor (SSTR) antagonist ciclosomatostatin (cicloSST). In contrast, SST does not regulate inhibition coming from interneurons. Because, SST is released by a class of local interneuron, it is concluded that this neuron helps to regulate the selection of motor acts.