EPIDIDYMAL SULFHYDRYL OXIDASE - SPERM-PROTECTIVE ENZYME FROM MALE REPRODUCTIVE-TRACT
EPIDIDYMAL SULFHYDRYL OXIDASE - SPERM-PROTECTIVE ENZYME FROM MALE REPRODUCTIVE-TRACT
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DOI：
10.1016/s0006-291x(75)80329-9
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发表时间：
1975-01-01
影响因子：
3.1
通讯作者：
MORTON, B
中科院分区：
文献类型：
--
作者：
CHANG, TSK;MORTON, B
在男性生殖道中发现了一种催化2R-SH + O2→R-S-S-R + H2O2反应的新酶。该酶对巯基化合物具有特异性，不需要辅因子即可发挥活性。从生理学角度来看，这种酶似乎可以保护精子的结构和功能免受内源性巯基的损害。因此，其抑制可能具有避孕意义。
A new enzyme catalyzing the reaction 2R-SH + O2→R-S-S-R + H2O2has been found in the male reproductive tract. The enzyme is specific for sulfhydryl compounds and does not require cofactors for activity. Physiologically, the enzyme appears to protect sperm structure and function against damage by endogenous sulfhydryls. Consequently its inhibition may be of contraceptive significance.