Cross-reactivity between peptide mimics of the immunodominant myelin proteolipid protein epitope PLP139-151:: Comparison of peptide priming in CFA vs. viral delivery
Cross-reactivity between peptide mimics of the immunodominant myelin proteolipid protein epitope PLP139-151:: Comparison of peptide priming in CFA vs. viral delivery
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DOI：
10.1016/j.jneuroim.2007.02.002
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Miller, Stephen D.
中科院分区：
文献类型：
--
作者：
Ercolini, Anne M.;Croxford, J. Ludovic;Miller, Stephen D.
流行病学证据表明，病原体可能引发自身免疫性疾病，如多发性硬化症（MS）的发展。病原体可以通过分子模拟触发疾病，其中针对外来表位产生的T细胞也与自身表位交叉反应。PLP 139 -151（SJL小鼠中的免疫显性CD 4（+）T细胞髓磷脂表位）的五种病原体衍生的分子模拟物先前被鉴定。本研究检查了不同模拟物之间的交叉反应性程度，比较了用CFA中的模拟肽致敏的小鼠与用重组模拟表达病毒感染的小鼠。体外反应性和诱导CNS疾病的能力的模式在肽引发和病毒感染之间是不同的。(c)2007 Elsevier B. V.保留所有权利。
Epidemiological evidence suggests that pathogens may trigger the development of autoimmune diseases such as multiple sclerosis (MS). Pathogens may trigger disease via molecular mimicry, wherein T cells generated against foreign epitopes are also cross-reactive with self-epitopes. Five pathogen-derived molecular mimics of PLP139-151 (the immunodominant CD4(+) T cell myelin epitope in SJL mice) were previously identified. This study examines the degree of cross-reactivity between the different mimics, comparing mice primed with mimic peptide in CFA with mice infected with recombinant mimic-expressing viruses. The pattern of in vitro reactivity and ability to induce CNS disease differs between peptide priming and virus infection. (c) 2007 Elsevier B.V. All rights reserved.