MECHANICAL RESPONSES OF RAT ISOLATED UTERINE HORNS TO TRANSMURAL STIMULATION
MECHANICAL RESPONSES OF RAT ISOLATED UTERINE HORNS TO TRANSMURAL STIMULATION
复制标题
大鼠离体子宫角对透壁刺激的机械反应
DOI：
10.1111/j.1476-5381.1975.tb07607.x
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发表时间：
1975
影响因子：
7.3
通讯作者：
M. Hollingsworth
中科院分区：
文献类型：
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作者：
M. Hollingsworth
1低脉宽经壁刺激大鼠离体子宫角产生宫缩。它们可被海莨菪碱或河豚毒素拮抗，而被肉毒杆菌碱增强。在迟缓激肽诱导的收缩过程中，经壁刺激产生抑制作用。这种抑制作用可被鸟乙啶、心得安或河豚毒素拮抗。六甲溴铵或吡定不影响对跨壁刺激的反应。提示跨壁刺激是一种刺激大鼠肌层胆碱能运动神经元和去甲肾上腺素能抑制神经元的方法。
1 Transmural stimulation of rat isolated uterine horns at low pulse width produced contractions. These were antagonized by hyoscine or tetrodotoxin and potentiated by physostigmine. 2 In the presence of hyoscine, and during bradykinin‐induced contractions, transmural stimulation produced inhibition. This inhibition was antagonized by guanethidine, propranolol or tetrodotoxin. 3 Hexamethonium or pempidine did not affect responses to transmural stimulation. 4 It is suggested that transmural stimulation is a method of exciting cholinergic motor and noradrenergic inhibitory postganglionic neurones to the rat myometrium.