Modulation of the formation of adhesions during the healing of injured tendons
Modulation of the formation of adhesions during the healing of injured tendons
复制标题
DOI：
10.1302/0301-620x.82b7.9892
复制
发表时间：
2000-09-01
影响因子：
--
通讯作者：
McGrouther, DA
中科院分区：
文献类型：
--
作者：
Khan, U;Kakar, S;McGrouther, DA
受伤后肌腱单位周围形成限制性粘连是外科医生面临的最令人烦恼的过程之一。在屈肌腱中，已表明滑膜组织是有助于这一过程的侵袭性成纤维细胞的来源。我们使用兔子模型检查了用抗代谢物 5-氟尿嘧啶 (5-FU) 治疗滑膜鞘五分钟的效果。比较治疗组和对照肌腱对损伤的反应中的炎症、增殖和分子标志物。与对照组相比，我们发现治疗组肌腱的增殖和炎症反应显着降低（p < 0.001）。不仅细胞和细胞因子反应减少，而且已知的促疤痕剂转化生长因子β 1 (TGF-β 1) 的活性水平也显着降低(p < 0.001)。这些试点研究表明，可以使用简单的单点触摸技术来调节限制性粘连的形成，以期产生更好的功能恢复。
The formation of restrictive adhesions around the musculotendinous unit after injury is one of the most vexing processes faced by the surgeon. In flexor tendons it has been shown that the synovial tissue is the source of aggressive fibroblasts which contribute to this process. Using a rabbit model, we have examined the effects of treating the synovial sheath with the antimetabolite 5-fluorouracil (5-FU) for five minutes. Inflammatory, proliferative and molecular markers were compared in the response of the treated and control tendons to injury, Compared with a control group we found that the proliferative and inflammatory responses were significantly reduced (p < 0.001) in the treated tendons. Not only was there a reduction in the cellular and cytokine response, but there also was a significant (p < 0.001) reduction in the level of activity of the known pro-scarring agent, transforming growth factor beta 1 (TGF-beta 1). These pilot studies indicate that the formation of restrictive adhesions may be modulated using a simple single-touch technique in the hope of producing a better return of function.