Low-Level Primary Blast Causes Acute Ocular Trauma in Rabbits
Low-Level Primary Blast Causes Acute Ocular Trauma in Rabbits
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DOI：
10.1089/neu.2015.4022
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发表时间：
2016-07-01
影响因子：
4.2
通讯作者：
Reilly, Matthew A.
中科院分区：
文献类型：
--
作者：
Jones, Kirstin;Choi, Jae-Hyek;Reilly, Matthew A.
这项研究的目的是利用活体动物模型，确定可存活的孤立原发原始细胞是否可以诱导出具有临床意义的眼外伤。18只荷兰腰带兔的双眼暴露在一个大型激波管中，模拟类似于简易爆炸装置的一次爆炸，承受各种可存活的低水平爆炸超压。冲击波暴露后的兔(以及5只对照兔)在冲击波前后进行彻底的眼部检查，以检测其变化。临床上角膜厚度的显著变化在冲击波后立即出现，并持续到48小时，提示内皮功能可能被破坏。视网膜厚度(RT)在暴露后即刻随比冲增加而增加。眼内压(TOP)与冲击波的比冲呈负相关。这些发现清楚地表明，可存活的原发冲击波导致眼部损伤，可能有临床和军事上的视觉功能后遗症。
The objective of this study was to determine whether clinically significant ocular trauma can be induced by a survivable isolated primary blast using a live animal model. Both eyes of 18 Dutch Belted rabbits were exposed to various survivable low-level blast overpressures in a large-scale shock tube simulating a primary blast similar to an improvised explosive device. Eyes of the blast-exposed rabbits (as well as five control rabbits) were thoroughly examined before and after blast to detect changes. Clinically significant changes in corneal thickness arose immediately after blast and were sustained through 48 h, suggesting possible disruption of endothelial function. Retinal thickness (RT) increased with increasing specific impulse immediately after exposure. Intraocular pressure (TOP) was inversely correlated with the specific impulse of the blast wave. These findings clearly indicate that survivable primary blast causes ocular injuries with likely visual functional sequelae of clinical and military relevance.