PHYSIOLOGICAL ASSAYS FOR BIOLOGICAL AGE IN MICE - RELATIONSHIP OF COLLAGEN, RENAL-FUNCTION, AND LONGEVITY
PHYSIOLOGICAL ASSAYS FOR BIOLOGICAL AGE IN MICE - RELATIONSHIP OF COLLAGEN, RENAL-FUNCTION, AND LONGEVITY
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DOI：
10.1080/03610738308258459
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发表时间：
1983-01-01
影响因子：
1.8
通讯作者：
ARCHER, JR
中科院分区：
文献类型：
--
作者：
HARRISON, DE;ARCHER, JR
通过尾腱纤维胶原蛋白变性时间和尿液浓缩能力来说明随年龄变化的生理变化。使用以下4个标准评价试验：随使用时间变化、重复性、与其他试验的关系以及与寿命的关系。当比较不同年龄的小鼠的9种基因型时，这些测试通常显示出随年龄的高度显著变化，两者似乎都与个体小鼠随后的寿命无关。当对11种小鼠基因型的平均值进行比较时，基因型的平均寿命与其平均胶原变性时间或平均肾浓缩能力在2个不同年龄段进行测试时没有显著相关性。对6种不同基因型的600-700日龄小鼠在同一个体中测试所有3个因素、胶原变性时间、尿浓缩能力和寿命之间的关系。在21个测试中，只有1个出现了轻微的显著相关性;这可能是偶然发生的。因此，尾腱胶原蛋白变性时间和尿液浓缩能力随年龄的变化相互独立，这些变化是无关的后续longevities，至少当线性关系进行了测试。显然，衰老是由不止一种机制来计时的。与实际年龄的强相关性并不一定表明独立测试将与寿命或彼此相关。
Tests of physiological changes with age are illustrated by collagen denaturation times of tail tendon fibers and urine concentrating abilities. The tests are evaluated using the following 4 criteria: change with age, repeatability, relationship to other assays and relationship to longevity. These tests usually showed highly significant changes with age when mice of different ages were compared for 9 mouse genotypes, neither appeared to be related to subsequent longevities of individual mice. When average values for 11 mouse genotypes were compared, the mean longevities of the genotypes were not significantly correlated with their mean collagen denaturation times or mean renal concentrating abilities, tested at 2 different ages. The relationships between all 3 factors, collagen denaturation times, urine concentrating abilities and longevities were tested in the same individuals for mice of 6 different genotypes at 600-700 days of age. Only 1 marginally significant correlation appeared out of 21 tested; this probably occurred by chance. Thus, tail tendon collagen denaturation times and urine concentrating abilities change with age independently of each other; these changes are unrelated to subsequent longevities, at least when linear relationships are tested. Apparently, aging is timed by more than 1 mechanism. Strong correlations with chronological age do not necessarily indicate that independent tests will be correlated with longevity or with each other.