Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: Evidence for increased CCK activity as a cause of the anorexia of aging
Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: Evidence for increased CCK activity as a cause of the anorexia of aging
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DOI：
10.1210/jc.86.12.5830
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发表时间：
2001-12-01
影响因子：
5.8
通讯作者：
Chapman, IM
中科院分区：
文献类型：
--
作者：
MacIntosh, CG;Morley, JE;Chapman, IM
健康的老龄化与食欲和食物摄入量的减少有关，即所谓的老年性厌食症，这可能导致蛋白质-能量营养不良。一个可能的原因厌食症的年龄是增加饱足效果的胆囊收缩素（CCK）。为了研究衰老对CCK饱腹效应的影响，12名年轻和12名老年健康受试者在试验餐前3天分别接受25分钟的生理盐水（对照）和CCK-8静脉输注，1 ng/kg/min或3 ng/kg/min。老年组进食量低于青年组，CCK-8抑制进食量21.6%，与对照组比较有显著性差异（P < 0.05）。老年受试者中CCK-8对能量摄入的抑制是年轻受试者的两倍（32 +/-6% vs. 16 +/-6%sFm，P < 0.05），并且与血浆CCK-8浓度相关，基线时较高（P < 0.05），老年受试者在CCK-8输注期间的升高幅度大于年轻受试者（P 0.01）。两个年龄组之间，血浆CCK-8浓度每升高一次对食物摄入的抑制程度没有差异（P = 0.35）。老年受试者基线时内源性CCK浓度较高（P < 0.001），在CCK-8输注期间降低，但对照组无此变化（P < 0.01），表明CCK抑制其自身释放。血浆瘦素浓度不受CCK输注的影响，而餐后胰岛素浓度降低，餐后葡萄糖峰值浓度延迟，但不受CCK-8输注的影响。由于老年人对外源性CCK的饱足效应保持敏感性，并且老年人血浆内源性CCK浓度较高，因此CCK活性增加可能有助于老年厌食症。
Healthy aging is associated with reductions in appetite and food intake-the so-called anorexia of aging,.which may predispose to protein-energy malnutrition. One possible cause of the anorexia of aging is an increased satiating effect of cholecystokinin (CCK). To investigate the impact of aging on the satiating effects of CCK, 12 young and 12 older healthy subjects received 25-min iv infusions of saline (control) and CCK-8, I ng/kg per min or 3 ng/k per min, on 3 separate days before a test meal. Older subjects ate less than young subjects, and food intake was suppressed 21.6% by CCK-8, compared with the control day (P < 0.05). The suppression of energy intake by CCK-8 in older subjects was twice that in young subjects (32 +/- 6% vs. 16 +/- 6% sFm, P < 0.05) and was related to plasma CCK-8 concentrations, which were higher at baseline (P < 0.05) and increased more during CCK-8 infusions in older than young subjects (P 0.01). The extent of suppression of food intake per given rise in plasma CCK-8 concentrations did not differ between the two age groups (P = 0.35). Endogenous CCK concentrations were higher at baseline in older subjects (P < 0.001) and decreased during the CCK-8 but not control infusions (P < 0.01), suggesting that CCK suppresses its own, release. Plasma leptin concentrations were not affected by CCK infusion, whereas postprandial insulin concentrations were lowered and the peak postprandial glucose concentration was delayed but not affected by CCK-8 infusion. Because older people retain their sensitivity to the satiating effects of exogenous CCK and plasma endogenous CCK concentrations are higher in older people, increased CCK activity may contribute to the anorexia of aging.