Evaluation of Activated Carbon Treatment on Overcoming the Interference of Rivaroxaban on the Detection of Functional Lupus Anticoagulant
Evaluation of Activated Carbon Treatment on Overcoming the Interference of Rivaroxaban on the Detection of Functional Lupus Anticoagulant
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DOI：
10.1159/000522324
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Chen Liu
中科院分区：
文献类型：
--
作者：
Songsong Lu;Nurzat Huerman;Meng Li;Qingming Ding;Ying Song;Qinzhu Xu;Jiang Rong;Jian Xu;Chen Liu
Objective: To study the role of activated carbon in eliminating the interference of rivaroxaban in the detection of lupus anticoagulants (LA)..Methods: Normal pooled plasma (NPP) was obtained as Group N1, and Group N2 took 1ml plasma from N1 and added activated carbon; Group N3 was prepared by mixing normal plasma with rivaroxaban, and Group N3 was treated with activated carbon according to our procedure, as Group N4. Plasma from 22 patients was collected before and 6-12 hours after rivaroxaban therapy, described as group P1 and group P2 respectively, and 1ml plasma was taken from Group P2 and treated with activated carbon, as Group P3. Anti-Xa and dRVVT / SCT index in each group were measured and compared..Results: Rivaroxaban concentrations and anti-Xa had high intercorrelations in Groups N3, and the levels of Anti-Xa and dRVVT / SCT index had high intercorrelations. After treatment with activated carbon, influence of rivaroxaban was removed, with lupus anticoagulant and coagulation factor assays not influenced. Rivaroxaban administration could affect lupus anticoagulant assay results in patients, with all LA results increased. After treatment with activated carbon, results of Anti-Xa and lupus anticoagulant tests recovered to the level before rivaroxaban therapy..Conclusions: We proposed a reference procedure for the LA detection of patients using rivaroxaban by activated carbon, and activated carbon was proven to be a simple product to eliminate the interference of rivaroxaban.
