Epidemiology of multiple Plasmodium falciparum infections -: 4.: Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity
Epidemiology of multiple Plasmodium falciparum infections -: 4.: Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity
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DOI：
10.1016/s0035-9203(99)90322-x
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发表时间：
1999-02-01
影响因子：
2.2
通讯作者：
Tanner, M
中科院分区：
文献类型：
--
作者：
Smith, T;Beck, HP;Tanner, M
通过汇编 1989 年至 1996 年间进行的 6 项不同社区研究的数据，研究了坦桑尼亚 Kilombero 河谷年龄与各种疟疾指数之间的关系。 1-5 岁儿童的恶性疟原虫感染率最高，而在一岁生日和青春期早期的康复率最低。结果，3-5岁儿童的患病率达到高峰。然而，一岁以下儿童的临床疟疾患病率（根据寄生虫血症导致腋窝温度高于或等于 375 摄氏度的超额风险估计）最高。感染多重性的高峰（通过聚合酶链反应-msp2位点限制性片段长度多态性鉴定）出现在3-7岁儿童中。婴儿和幼儿（1-2 岁）的寄生虫密度和感染复数之间存在显着相关性，但在老年人中则不然。
The relationship between age and various malariological indices in the Kilombero valley of Tanzania were examined by compiling data from 6 different community studies carried out between 1989 and 1996. The rate of acquisition of Plasmodium falciparum infection was highest in children 1-5 years of age, while recovery rates were lowest between the first birthday and early adolescence. As a result, peak prevalence was reached in 3-5 years old children. However, the prevalence of clinical malaria (estimated from the excess risk of axillary temperatures greater than or equal to 375 degrees C attributable to parasitaemia) was highest in children under one year of age. The peak in multiplicity of infection (identified by polymerase chain reaction-restriction fragment length polymorphism of the msp2 locus) occurred in 3-7 years old children. There was a significant correlation between parasite density and multiplicity of infection in infants and young children (1-2 years of age) but not in older individuals.