Effects of an elemental diet in healthy volunteers.
Effects of an elemental diet in healthy volunteers.
复制标题
元素饮食对健康志愿者的影响。
DOI：
10.1016/s0016-5085(73)80127-1
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发表时间：
1973
期刊：
影响因子：
29.4
通讯作者：
Gustavo Bounous
中科院分区：
文献类型：
--
作者：
Jean Perrault;Ghislain Devroede;Gustavo Bounous
18名健康志愿者被随机分配只吃元素饮食（Mead-Johnson 3200-AS）或对照饮食（Mead-Johnson 3200-Au），不同之处在于蛋白质部分未水解，并且没有中链甘油三酯添加到脂质部分。这两种饮食对血清生化和血液学参数，肝脏分泌的胆盐，胰腺分泌的酶在标准刺激下，和不透射线标记物的通过时间有很大的影响。对照组受试者的平均体重从147磅降至145磅（P <0.01），元素组从148磅降至145磅（P <0.001）。对照组血清胆固醇从203 mg/100 ml降至159 mg/100 ml（P <0.01），元素组从204 mg/100 ml降至189 mg/100 ml（P> 0.05）。得出的结论是，本研究中研究的元素饮食可安全用于人类至少12天。
Eighteen healthy volunteers were assigned at random to eat exclusively either an elemental diet (Mead-Johnson 3200-AS) or a control diet (Mead-Johnson 3200-AU), which differed in that the protein fraction was not hydrolyzed and no medium chain triglycerides were added to the lipid fraction. Neither diet had much effect on serum biochemical and hematological parameters, hepatic secretion of bile salts, pancreatic secretion of enzymes under standard stimuli, and transit time of radio-opaque markers. Mean weight of the subjects decreased from 147 to 145 lb (P< 0.01) in the control group and from 148 to 145 lb (P< 0.001) in the elemental group. Serum cholesterol decreased from 203 to 159 mg per 100 ml (P< 0.01) in the control group and from 204 to 189 mg per 100 ml (P>0.05) in the elemental group. It is concluded that the elemental diet investigated in this study is safe for human use for a period of at least 12 days.