Increased Serum 90K and Galectin-3 Expression Are Associated with Advanced Stage and a Worse Prognosis in Diffuse Large B-Cell Lymphomas
Increased Serum 90K and Galectin-3 Expression Are Associated with Advanced Stage and a Worse Prognosis in Diffuse Large B-Cell Lymphomas
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DOI：
10.1159/000193223
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Kim, In Sun
中科院分区：
文献类型：
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作者：
Kim, Seok Jin;Lee, Seung Jin;Kim, In Sun
90 K和半乳糖凝集素-3在细胞与细胞外基质粘附和肿瘤转移中的作用已有报道，但对它们在弥漫性大B细胞淋巴瘤（DLBCL）预后和淋巴结受累中的作用知之甚少。因此，我们在新诊断的DLBCL患者中通过酶联免疫吸附测定法测定血清90 K浓度，并通过免疫组织化学法测定半乳糖凝集素-3的组织表达。DLBCL患者的平均血清90 K浓度高于健康对照（1，408.81 +/-889.45 vs. 980.94 +/- 58.69 ng/ml，p = 0.036）。高血清90 K（中值>= 1，249.50 ng/ml）和高半乳糖凝集素-3表达（> 75%的细胞中的3级阳性染色）显示与III/IV期、6 2结受累和高/高-中等国际预后指数的风险显著相关（p < 0.05）。低90 K组完全缓解率（CR）为86.9%，20/23，高于高90 K组的56.5%，13/23。Galectin 3高表达的14例患者中，仅6例患者显示CR（42.9%）。90 K和galectin-3高表达组的进展时间和总生存期较短（p
The role of 90K and galectin-3 in cell-to-extracellular matrix adhesion and tumor metastasis has been reported, but little is known about their role in the prognosis and extranodal involvement of diffuse large B-cell lymphomas (DLBCL). Thus, we measured serum 90K concentration by enzyme-linked immunosorbent assay and tissue expression of galectin-3 by immunohistochemistry in newly diagnosed DLBCL patients. The mean serum 90K concentration was higher in DLBCL than in healthy controls (1,408.81 +/- 8 89.45 vs. 980.94 +/- 58.69 ng/ml, p = 0.036). High serum 90K (median value >= 1,249.50 ng/ml) and high galectin-3 expression (grade 3 positive staining in > 75% of cells) showed a significant association with stage III/IV, 6 2 extranodal involvements and risk of high/high-intermediate international prognostic index (p < 0.05). The complete response (CR) rate (86.9%, 20/23) in the low 90K group was higher than in the high 90K group (56.5%, 13/23). Among 14 patients with high galectin 3 expression, only 6 patients showed CR (42.9%). The time to progression and overall survival were shorter in the group with high 90K and galectin-3 expression (p