Clinicopathological significance of invasive micropapillary carcinoma component in invasive breast carcinoma
Clinicopathological significance of invasive micropapillary carcinoma component in invasive breast carcinoma
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DOI：
10.1111/j.1440-1827.2011.02735.x
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发表时间：
2011-12-01
影响因子：
2.2
通讯作者：
Akiyama, Futoshi
中科院分区：
文献类型：
--
作者：
Ide, Yoshimi;Horii, Rie;Akiyama, Futoshi
乳腺浸润性微乳头状癌（IMP）是一种罕见的浸润性乳腺癌的变种，大多数IMP病例与淋巴结转移和淋巴管浸润有关。仅由IMP组分组成的病变很少见，几乎总是与其他病理组分共存。然而，很少有报道记载IMP沿着其比例和共存的病理类型。我们分析了1998年在我院手术的486个乳腺癌病灶。我们根据每处病变中IMP组分的比例将病变分为五组。观察各组淋巴结转移和淋巴管浸润的发生率。浸润性癌的发生率为8.4%。有IMP成分的病灶淋巴结转移率和淋巴管浸润率明显高于无IMP成分的病灶，但淋巴结转移率与病理类型、瘤簇形态、核分级及雌激素受体、孕激素受体、IMP组分中人表皮生长因子受体2和巨囊性疾病液蛋白-15。IMP成分的存在是淋巴结转移的一个重要预测因素，即使它只在一小部分肿瘤中被检测到。
Invasive micropapillary carcinoma (IMP) of the breast is a rare variant of invasive breast carcinoma and most cases of IMP are associated with nodal metastasis and lymphatic invasion. Lesions composed of an IMP component alone are rare and almost always coexist with other pathological components. However, few reports have documented IMP along with its proportion and the coexistent pathological type. We analyzed the total 486 breast cancer lesions operated in our hospital in 1998. We classified the lesions into five groups by the proportion of the IMP component in each lesion. Then we evaluated the incidence of nodal metastasis and lymphatic invasion in each group. The incidence of the invasive carcinoma containing any IMP components was 8.4%. The incidence of nodal metastasis and lymphatic invasion in lesions with an IMP component were significantly higher than that in those with no IMP. No correlation was seen between the incidence of nodal metastasis and the coexistent pathological type, shape of tumor clusters, nuclear grade and the expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 and gross cystic disease fluid protein-15 in IMP components. The presence of IMP components was a significant predictive factor for nodal metastasis, even if it is detected in only a small proportion of the tumor.